R05DA04 - Codeine |
Probably not porphyrinogenic |
PNP |
Rationale
Opioid substrate for CYP2D6 and 3A4. Several references consider it safe for use.
Chemical description
Opioide with analgetic and antitussive properties. Demetylated by CYP2D6 and 3A4. Inhibitor of 2D6.
IPNet drug reports
Uneventful use reported in 27 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.
Anderson KE. Biochim Biophys Acta. 1978 Oct; 543(3):313-27.
|
708789 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 3. | French List
Centre Français des Porphyries
|
|
| 4. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 5. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Codeinefosfaat · Codeïnefosfaat · Melrosum 
Bronchodine · Bronchosedal Codeine · Codeine · Codeinoform · Codocalyptol 
neo Codion · Paderyl 
Codeisan · Fludan Codeína · Histaverin · Notusin · Toseina 
Codinep 
Hederix Plan 
Codeina · Fosfat Codeina 
Codein · Codicalm · Coditussin · Dropa Codein · GEM Codein · Iropect · Makatussin 
Benylin with Codeine · Bepro · Codeine · Codeine phosphate · Galcodine 
Kodein 
Kodein 
Kodein 
HERBAPini · Neoazarina · Sirupus Pini compositus 
Lertus 
Codeine 
Codeine · Colinctus · l.t.r. · Linctus Tussis Rubra 
Codeine · Codeine Contin · Linctus Codeine Blanc 
Bronchosedal Codeine · Codeine · neo-Codion 
Kodeinfosfat 
Codeini Phosphatis · Kodeinijev 
Codein · Kodein 
Codiene