Monograph
R06AD01 - Alimemazine |
Propably not porphyrinogenic |
PNP |
Rationale
Phenotiazines in general are considered safe in several references.
Chemical description
High dose (tabl 40-300 mg/d) phenotiazine neuroleptic with sedative and antiallergic properties, used e.g. as tranquillizer in alcoholism, as premedication, in itching and allergic conditions. French list: authorized South African list: use with care Kalman, Bonkowski: safe Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
IPNet drug reports
Uneventful use reported in 6 patients with acute porphyria.
Similar drugs
Tradenames and packages
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