R06AD02 - Promethazine |
Probably not porphyrinogenic |
PNP |
Rationale
Substrate for CYP2B6 and 2D6. Phenotiazines in general are considered safe in several references.
Chemical description
High dose phenothiazine used (tabl 5-500 mg/d) as tranquillizer, antiallergic, and against motion sickness. Metabolized by CYPs 2B6 and 2D6, Inhibitor of 2 D6.
Personal communication
Used in porphyria ward (Sweden).
IPNet drug reports
Uneventful use reported in 6 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.
Anderson KE. Biochim Biophys Acta. 1978 Oct; 543(3):313-27.
|
708789 |
| 2. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 3. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 4. | French List
Centre Français des Porphyries
|
|
| 5. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Promethazine 
Pipolphen 
Fadezin · Farganesse · Prometazina 
Avomine · Phenergan · Phenergan Nightime · Promethazine · Promethazine hydrochloride · Promethazine teoclate · Sominex · Vertigon · Ziz · Ziz Forte 
Phenergan · Prometazin 
Farghess · Lergigan · Phenergan · Phénergan · Prometazin · Promethazin · Promethazine 
Phenergan · Promethazin 
Diphergan · Polfergan 
Allersoothe · Avomine · Goodnight · Meth-Zine · Phenercalm · Phenergan · Promethazine · Prozine 
Axcel Promethazine · Promagen · Promethazine · Promezine · Prozine · Votazine · Xepagan 
Histantil 
Phenergan · Prometazin 
Promethazine 
Promethazine 
Prothazin 
Prometozine