Monograph
R06AX22 - Ebastine |
Propably not porphyrinogenic |
PNP |
Rationale
Ebastine is not found to be an inducer or mechanism-based inhibitor of any major CYP enzymes, and no pharmacokinetic porphyrinogenic effects are suspected.
Chemical description
Histamine H1-receptor antagonist.
Therapeutic characteristics
Ebastine is an antiallergic agent used in the treatment of allergic rhinitis, conjunctivitis and urticaria.
It is administered orally.
Metabolism and pharmacokinetics
Ebastine is subject to rapid and extensive first pass metabolism in the liver by CYP enzymes (SPC). CYP 3A4 and CYP 2J2 are the main enzymes that metabolizes ebastine to desalkylebastine and hydroxyebastine. Hydroxyebastine is further metabolized to carebastine, which is pharmacologically active (Liu 2006).
Clinical drug-drug interaction studies have been carried out, mostly studying the potential effects other drugs (mainly CYP-inhibitors) have on ebastine as a substrate of CYP 3A4 (Rico 2009).
No drug-drug interaction with ebastine as a perpetrator is described or suspected in interaction databases Preissner 2010, NOMA, Lexi-Interact, The Danish Health and Medicines Authority).
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.
Liu KH, Kim MG, et al. Drug Metab Dispos. 2006 Nov;34(11):1793-7. |
16896065 |
| 2. | SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions.
Preissner S, Kroll K,et al. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. |
19934256 |
| 3. | Ebastine in the light of CONGA recommendations for the development of third-
Rico S, Antonijoan RM, et al. generation antihistamines J Asthma Allergy. 2009; 2: 73–92. |
21437146 |
| * | Government bodies | |
| 4. | Norwegian medicines agency (NOMA). Find medicine.
|
|
| * | Drug interaction databases | |
| 5. | Lexi-Interact, via UpToDate.
|
|
| 6. | The Danish Health and Medicines Authority. The drug interaction database.
|
|
| * | Summary of Product Characteristics | |
| 7. | Norwegian medicines agency (NOMA). Summary of Product Characteristics (SPC). (Kestine).
|
|
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Ebastine Aurobindo Smelt 10 mg, orodispergeerbare tabletten · Ebastine Teva smelt 10 mg, orodispergeerbare tabletten · Kestine 10, filmomhulde tabletten 10 mg · Kestine 20, filmomhulde tabletten 20 mg · Kestine Smelt 10 mg, lyophilisaat voor oraal gebruik · Kestine Smelt 20 mg, lyophilisaat voor oraal gebruik · Notaxo 10 mg, orodispergeerbare tabletten · Notaxo 20 mg, orodispergeerbare tabletten 
Ebastine Sandoz 10 mg compr. orodisp. · Ebastine Sandoz 20 mg compr. orodisp. · Ebastine Teva 10 mg compr. orodisp. · Ebastine Teva 10 mg compr. pellic. · Ebastine Teva 20 mg compr. orodisp. · Ebastine Teva 20 mg compr. pellic. · Estivan 10 mg compr. pellic. · Estivan 20 mg compr. pellic. · Estivan Lyo 10 mg lyoph. or. · Estivan Lyo 20 mg lyoph. or. 
ALASTINA 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · ALASTINA 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · BACTIL 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Bactil Flas 10 mg Liofilizados Orales · BACTIL FORTE 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Bactil Forte Flas 20 mg Liofilizados Orales · Ebastel · EBASTEL 1 mg/ml SOLUCI?N ORAL · EBASTEL FLAS 10 mg LIOFILIZADOS ORALES · Ebastel Forte · EBASTEL FORTE 20 mg COMPRIMIDOS RECUBIERTOS CON PEL?CULA · EBASTEL FORTE FLAS 20 mg LIOFILIZADOS ORALES · Ebastina · Ebastina Alprofarma 10 mg Comprimidos Recubiertos con Pelicula efg · Ebastina Alprofarma 20 mg Comprimidos Recubiertos con Pelicula efg · EBASTINA ALTER 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA ALTER 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ebastina Apotex 10 mg Comprimidos Bucodispersables efg · Ebastina Apotex 20 mg Comprimidos Bucodispersables efg · Ebastina Aristo 10 mg Comprimido Bucodispersables efg · Ebastina Aristo 10 mg Comprimidos Recubiertos con Pelicula efg · Ebastina Aristo 20 mg Comprimidos Recubiertos con Pelicula efg · Ebastina Aurobindo 10 mg Comprimidos Bucodispersables efg · Ebastina Aurobindo 20 mg Comprimidos Bucodispersables efg · Ebastina Aurovitas 10 mg Comprimidos Bucodispersables efg · Ebastina Aurovitas 20 mg Comprimidos Bucodispersables efg · Ebastina Brown 10 mg Comprimidos Bucodispersables efg · EBASTINA CINFA 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA CINFA 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ebastina Cinfalab 10 mg Comprimidos Recubiertos con pel?Cula · EBASTINA COMBIX 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA COMBIX 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ebastina Flas Cinfa 10 mg Comprimidos Bucodispersables efg · Ebastina Flas Cinfa 20 mg Comprimidos Bucodispersables efg · Ebastina Flas Stada 10 mg Comprimidos Bucodispersables efg · Ebastina Forte · Ebastina Forte Flas Stada 20 mg Comprimidos Bucodispersables efg · Ebastina Gador 10 mg Comprimidos Bucodispersables efg · Ebastina Gador 20 mg Comprimidos Bucodispersables efg · Ebastina Kern Pharma 10 mg Comprimidos Bucodispersables efg · EBASTINA KERN PHARMA 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ebastina Kern Pharma 20 mg Comprimidos Bucodispersables efg · EBASTINA KERN PHARMA 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ebastina Normon 10 mg Comprimidos Bucodispersables efg · Ebastina Normon 20 mg Comprimidos Bucodispersables efg · EBASTINA NORMON 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA QUALIGEN 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA QUALIGEN 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ebastina Quasset · Ebastina Quasset 20 mg Comprimidos Bucodispersables efg · Ebastina Ratiopharm 10 mg Comprimidos Bucodispersables efg · Ebastina Ratiopharm 20 mg Comprimidos Bucodispersables efg · Ebastina Sandoz 10 mg Comprimidos Bucodispersables efg · EBASTINA SANDOZ 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA SANDOZ 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA STADA 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA TARBIS 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA TECNIGEN 20 mg COMPRIMIDOS EFG · Ebastina Teva Group 10 mg Comprimidos Recubiertos con pel?Cula efg · Ebastina Teva Group 20 mg Comprimidos Recubiertos con pel?Cula efg · Ebastina Teva-Ratiopharm 10 mg Comprimidos Bucodispersables efg · Ebastina Teva-Ratiopharm 20 mg Comprimidos Bucodispersables efg · EBASTINA TEVAGEN 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA TEVAGEN 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ebastina Viatris 10 mg Comprimidos Recubiertos con Pelicula efg · Ebastina Viatris 20 mg Comprimidos Bucodispersables efg · Ebastina Viatris 20 mg Comprimidos Recubiertos con Pelicula efg · EBASTINA VIR 10 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · EBASTINA VIR 20 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG 
Clever · Ebastina · Kestine 
Ebastin Brown · Kestine · Kestine Flash · Pollastin 
Ebastin Orifarm · Kestine 
Evastix 
Estivan · Estivan lyo 
Kestine · Kestine Flash 
Ebastin Orion · Kestine · Kestine Lyo · Kestox 
Kestine 
Ebastin Aristo
© NAPOS 2025