Monograph
R06AX26 - Fexofenadine |
Propably not porphyrinogenic |
PNP |
Rationale
Fexofenadine is not an inducer or an irreversible inhibitor of Cytochrome P450 enzymes. There are no indications of porphyrinogenic effects connected with the pharmacodynamic properties of the drug.
Chemical description
Fexofenadine is a butyrophenone-derivative antihistamine. The drug is the active carboxylic acid metabolite of terfenadine.
Therapeutic characteristics
Fexofenadine is a selective histamine H1-receptor antagonist, and it is used in the symptomatic relief of allergic conditions including seasonal allergic rhinitis. It is administered orally. Fexofenadine is not suspected to have any potentially porphyrinogenic side effects.
Metabolism and pharmacokinetics
Only about 5% of the total dose of fexofenadine is metabolised, mostly by the intestinal mucosa, with 0.5 to 1.5% of the dose undergoing hepatic biotransformation by the cytochrome P450 system. Fexofenadine is a substrate of CYP 3A4 and an inhibitor of CYP 2D6, but is not listed as an inducer or irreversible inhibitor of Cytochome P450 enzymes (Rendic 2002).
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Rendic, S. Summery of information on human CYP enzymes: human P450 metabolism. Drug metabolism reviews 2002; 34(1&2), 83-448.
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| 2. | Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine, a comparative review. Clin Pharmacokinet 2008; 47 (4): 217-230
Devillier P, Roche N et al. |
18336052 |
| * | Drug reference publications | |
| 3. | Sweetman SC, editor. Martindale: The complete drug reference. Fexofenadine. Pharmaceutical Press 2009.
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| * | Summary of Product Characteristics | |
| 4. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Telfast.
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Tradenames
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Allegra fexotabs, 120 mg omhulde tabletten · Fexofenadine HCL Amarox 120 mg, filmomhulde tabletten · Fexofenadine HCL Amarox 180 mg, filmomhulde tabletten · Fexofenadine HCl Aurobindo 120 mg, filmomhulde tabletten · Fexofenadine HCl Aurobindo 180 mg, filmomhulde tabletten · Fexofenadine HCl Mylan 120 mg, filmomhulde tabletten · Fexofenadine HCL Mylan 180 mg, filmomhulde tabletten · Fexofenadine HCl Teva 120 mg, filmomhulde tabletten · Fexofenadine HCl Teva 180 mg, filmomhulde tabletten · Fexofenadine HCl Viatris 120 mg, filmomhulde tabletten · Fexofenadine HCl Viatris 180 mg, filmomhulde tabletten · Telfast 180 mg, omhulde tabletten · Telfast Junior 30 mg, filmomhulde tabletten 
Allegra tab 120 mg comp. · Telfast 180 mg comp. 
Fexofenadina Aurovitas Pharma 120 mg Comprimidos Recubiertos con Pelicula efg · Fexofenadina Cipla 120 mg Comprimidos Recubiertos con Pelicula efg · Fexofenadina Cipla 180 mg Comprimidos Recubiertos con Pelicula efg · FEXOFENADINA OPELLA 180 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · TELFAST 120 mg COMPRIMIDOS RECUBIERTOS CON PELICULA 
Fexofenadina · Fixodin · Telfast 
Allevia · Fexofenadine · Histallay · Telfast · Treathay 
Alnodine · Alterfast · Altifex · Clarifast · Fexofenadin Cipla · Fexofenadine Viatris · Fexofenadinhydrochlorid Mashal · Histafast · Nefoxef · Telfast 
Altifex · Feksofenadin Cipla · Telfast 
Allegra · Allegra Telfast 180 · ALLERTEC Fexo · Fexofast 120 mg · Fexofast 180 mg · Fexofenadine Aurovitas · Fexofenadine hydrochloride Cipla · Fexofenadini Hydrochloridum Polpharma · Telfast 30 · Telfexo 120 mg · Telfexo 180 mg 
Allegra tab · Telfast 
Fexofenadine Viatris · Nefoxef · Telfast 
Fexofenadine ratiopharm · Telfast 
AleriX® · Allegra®
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