S01AA01 - Chloramphenicol |
Probably not porphyrinogenic |
PNP |
Rationale
Possibly insignificant systemic exposure.
Chemical description
Broadspectrum antibiotic in eye drops 5mg/mL (one drop, i.e. About 100µg, every third hour for two days).
IPNet drug reports
Uneventful use reported in 3 patients with acute porphyria. One report of an acute porphyric attack in a susceptible male with AIP, but the attack was poorly documented. This report has therefore not been taken into account in the judgement of the porphyrinogenicity of chloramphenicol eye drops.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| Porphyria Drug Lists | ||
| 2. | French List
Centre Français des Porphyries
|
|
| 3. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 4. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Chlooramfenicol 
Oftalmolosa Cusi Cloramfenicol 
Flogocyn · Visiocetina 
Boots Pharmacy Antibiotic · Brochlor · Brolene Antibiotic · Chloramphenicol · Chloramphenicol Antibiotic · Chloromycetin · Chloromycetin Redidrops · Clorogen · Golden Eye Antibiotic · Klorafect · Lloydspharmacy Chloramphenicol Antibiotic · Minims chloramphenicol · Optrex Bacterial Conjunctivitis · Optrex Infected Eyes · Tubilux Infected Eyes 
Kloramfenikol 
Chloramphenicol · Chloromycetin · Kloramfenikol · Kloramfenikol Chauvin 
Kloramfenikol 
Chlorafast · Chloramphenicol · Chloromycetin · Chloroptic · Chloroptic SOP · Chlorsig · Econochlor · Fenicol · Isopto Fenicol · Ocuzo 
Xepanicol 
Oftan Chlora 
Oftan Akvakol · Oftan Chlora 
Oftan Akvakol 
Oftan Akvakol 
Chloramphenicol · Hloramfenikol 
Chloramphenicol · Clorocil