Monograph
A10BB07 - Glipizide |
Propably not porphyrinogenic |
PNP |
Rationale
Glipizide is metabolized by CYP2C9. There are no clinical studies indicating that glipizide is an inhibitor or inducer of CYP enzymes.
Risk for gastrointestinal adverse events in the form of nausea, vomiting and diarrhoea motivates vigilance against insufficient intake of food, especially of carbohydrate.
Chemical description
sulfonylurea antidiabetic.
Therapeutic characteristics
Glipizide is indicated for the treatment of type 2 diabetes.
Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are nausea, vomiting, diarrhoea, obstipation and abdominal pain. A less common side effect is hypoglycaemia, which also may be potentially porphyrinogenic.
Metabolism and pharmacokinetics
Glipizide is metabolized by CYP2C9 (Rogers 2002) and the elimination half-life is 2-4 hours.
There are no clinical studies indicating that glipizide is an inhibitor or inducer of CYP enzymes.
Personal communication
C.Andersson; patient reports: tolerated (n=1)
Published experience
Glipizide is listed to have been associated with acute porphyria attacks in humans (Moore 1997).
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Drugs in the acute porphyrias--toxicogenetic diseases. Cell Mol Biol (Noisy-le-grand). 1997 Feb;43(1):89-94.
Moore MR, Hift RJ. |
9074793 |
| 2. | Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs.
Rogers JF, Nafziger AN, et al. Am J Med. 2002 Dec 15;113(9):746-50. |
12517365 |
| * | Summary of Product Characteristics | |
| 3. | Norwegian medicines agency. Summary of Product Characteristics (SPC). glipizid.
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