Monograph
A10BG03 - Pioglitazone |
Propably not porphyrinogenic |
PNP |
Rationale
Pioglitazone is a substrate of CYP2C8, CYP2C9 and CYP3A4, but is not an inducer of them or CYP1A. Pioglitazone does not inhibit CYP2C8 or CYP3A4.
Chemical description
Pyridyl ethoxybenzyl thiazolidindione
Therapeutic characteristics
Common side effects are back pain and upper respiratory tract infections.
Hepatic exposure
Irrelevant
Metabolism and pharmacokinetics
Pioglitazone is listed to be metabolized by CYP2C8, CYP2C9 and CYP3A4 (Kajosaari 2006, Norsk legemiddelhåndbok, Scheen 2007). The elimination half-life is 5-6 hours.
Clinical studies showed no induction of CYP1A, CYP2C8, CYP2C9 (SPC) or CYP3A4 (Nowak 2002, Scheen 2007, SPC).
Pioglitazone inhibits CYP2C8 and CYP3A4 (Kajosaari 2006, Scheen 2007), and has also been shown to be a mechanism-based inhibitor of CYP3A4 in vitro (Lim 2005, Sinz 2006). In vivo studies have however, shown that pioglitazone does not increase the plasma concentration of repaglinide, a CYP2C8 and CYP3A4 substrate, which indicates that pioglitazone does not significantly inhibit these enzymes (Kajosaari 2006, Scheen 2007).
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide.
Kajosaari LI, Jaakkola T, et al. Eur J Clin Pharmacol. 2006 Mar;62(3):217-23. |
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| 2. | Pioglitazone: effect on CYP3A4 activity.
Nowak SN, Edwards DJ, et al. J Clin Pharmacol. 2002 Dec;42(12):1299-302. |
12463723 |
| 3. | Pharmacokinetic interactions with thiazolidinediones.
Scheen AJ. Clin Pharmacokinet. 2007;46(1):1-12. |
17201456 |
| 4. | Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions.
Sinz M, Kim S, et al. Curr Drug Metab. 2006 May;7(4):375-88. |
16724927 |
| * | Drug reference publications | |
| 5. | Norsk legemiddelhåndbok. Pioglitazone
|
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| * | Summary of Product Characteristics | |
| 6. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Pioglitazone.
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
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Actos 15 mg tablet, tabletten · Actos 30 mg tablet, tabletten · Actos 45 mg tablet, tabletten · Glidipion 15 mg tabletten · Glidipion 30 mg tabletten · Glidipion 45 mg tabletten · Glustin 45 mg tablet, tabletten · Pioglitazon Accord 15 mg tabletten · Pioglitazon Accord 30 mg tabletten · Pioglitazon Accord 45 mg tabletten · Pioglitazon Aurobindo 30 mg tabletten · Pioglitazon Aurobindo 45 mg tabletten · Pioglitazon Sanovel 30 mg tabletten · Pioglitazon Sanovel 45 mg tabletten · Pioglitazone Actavis 15 mg tabletten · Pioglitazone Actavis 30 mg tabletten · Pioglitazone Actavis 45 mg tabletten 
Actos 15 mg comp. · Actos 30 mg comp. · Actos 45 mg comp. · Pioglitazone Accord 15 mg comp. · Pioglitazone Accord 30 mg comp. · Pioglitazone Accord 45 mg comp. · Pioglitazone Actavis 15 mg comp. · Pioglitazone Actavis 30 mg comp. · Pioglitazone Actavis 45 mg comp. · Pioglitazone Teva Pharma 15 mg comp. · Pioglitazone Teva Pharma 30 mg comp. · Pioglitazone Teva Pharma 45 mg comp. 
ACTOS 15 mg COMPRIMIDOS · ACTOS 30 mg COMPRIMIDOS · GLUSTIN 15 mg COMPRIMIDOS · GLUSTIN 30 mg COMPRIMIDOS · Pioglitazona · PIOGLITAZONA ACCORD 15 mg COMPRIMIDOS EFG · PIOGLITAZONA ACCORD 30 mg COMPRIMIDOS EFG · PIOGLITAZONA ACTAVIS 15 mg COMPRIMIDOS (56 COMP.) EFG · PIOGLITAZONA ACTAVIS 30 mg COMPRIMIDOS (28 COMP.) EFG · PIOGLITAZONA ACTAVIS 30 mg COMPRIMIDOS (56 COMP.) EFG · Pioglitazona Aurobindo 15 mg Comprimidos efg · Pioglitazona Aurobindo 30 mg Comprimidos efg · Pioglitazona Aurovitas 15 mg Comprimidos efg · Pioglitazona Aurovitas 30 mg Comprimidos efg · Pioglitazona Edigen 15 mg Comprimidos efg · Pioglitazona Edigen 30 mg Comprimidos efg · PIOGLITAZONA NORMON 15 mg COMPRIMIDOS EFG · PIOGLITAZONA NORMON 30 mg COMPRIMIDOS EFG · PIOGLITAZONA STADA 15 mg COMPRIMIDOS EFG · PIOGLITAZONA STADA 30 mg COMPRIMIDOS EFG · PIOGLITAZONA TEVA PHARMA 15 mg COMPRIMIDOS (28 COMPRIMIDOS) EFG · PIOGLITAZONA TEVA PHARMA 30 mg COMPRIMIDOS (28 COMPRIMIDOS) EFG · PIOGLITAZONA TEVA PHARMA 30 mg COMPRIMIDOS (56 COMPRIMIDOS) EFG 
Actos · Pioglitazone 
PIOGLITAZONE ACCORD 15 mg · PIOGLITAZONE ACCORD 30 mg · PIOGLITAZONE ACCORD 45 mg 
Actos · Diabiom · Glidipion · Glizofar · Pioglitazone 
Actos · Glidipion · Paglitaz · Pioglitazon Actavis · Pioglitazone Accord 
Actos · Pioglitazone Accord 
Actos · Pioglitazone Accord · Pioglitazone Actavis · Pioglitazone Bioton · Pioglitazone Teva 
Actos · Paglitaz · Paglitaz-45 · Pioglitazone Accord 
Actos · Pioglitazone Accord · Pioglitazone Actavis 
Actos · Glidipion · Pioglitazone Accord · Pioglitazone Actavis 
Actos · Pioglitazone Accord · Pioglitazone Actavis · Zipion 
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