Monograph
A10BX02 - Repaglinide |
Propably not porphyrinogenic |
PNP |
Rationale
Repaglinide does not induce or inhibit CYP3A4.
Risk for gastrointestinal adverse events in the form of abdominal pain and diarrhoea motivates vigilance against insufficient intake of food, especially of carbohydrate.
Chemical description
Carbamoylmethyl benzoic acid derivative
Therapeutic characteristics
Repaglinide is indicated for the treatment of diabetes type 2 as monotherapy or in combination with metformin.
Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are abdominal pain and diarrhoea.
Hepatic exposure
Probably not significant
Metabolism and pharmacokinetics
Repaglinide is metabolized mainly by CYP2C8 and to a smaller degree by CYP3A4 (SPC).
Repaglinide was co-administrated with theophylline, a CYP3A4 substrate, and did not induce or inhibit theophylline (Hatorp 2000).
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Drug interaction studies with repaglinide: repaglinide on digoxin or theophylline pharmacokinetics and cimetidine on repaglinide pharmacokinetics.
Hatorp V, Thomsen MS. J Clin Pharmacol. 2000 Feb;40(2):184-92. |
10664925 |
| * | Summary of Product Characteristics | |
| 2. | Norwegian medicines agency. Summary of Product Characteristics (SPC). repaglinid.
|
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Enyglid 0,5 mg, tablets · Enyglid 1 mg, tablets · Enyglid 2 mg, tablets · NovoNorm, 0,5 mg tabletten · NovoNorm, 1 mg tabletten · NovoNorm, 2 mg tabletten · Prandin 0,5 mg, tabletten · Prandin 1 mg, tabletten · Prandin 2 mg, tabletten · Repaglinide Accord 0,5 mg tabletten · Repaglinide Accord 1 mg tabletten · Repaglinide Accord 2 mg tabletten · Repaglinide Krka 0,5 mg tabletten · Repaglinide Krka 1 mg tabletten · Repaglinide Krka 2 mg tabletten · Repaglinide STADA 0,5 mg, tabletten · Repaglinide STADA 1 mg, tabletten · Repaglinide STADA 2 mg, tabletten · Repaglinide STADA 4 mg, tabletten · Repaglinide Teva 0,5 mg, tabletten · Repaglinide Teva 1 mg, tabletten · Repaglinide Teva 2 mg, tabletten 
Enyglid 0.5 mg comp. · Enyglid 1 mg comp. · Enyglid 2 mg comp. · NovoNorm 0.5 mg comp. · NovoNorm 1 mg comp. · NovoNorm 2 mg comp. · Prandin 0.5 mg comp. · Prandin 1 mg comp. · Prandin 2 mg comp. · Repaglinide Accord 0.5 mg comp. · Repaglinide Accord 1 mg comp. · Repaglinide Accord 2 mg comp. · Repaglinide EG 0.5 mg comp. · Repaglinide EG 1 mg comp. · Repaglinide EG 2 mg comp. · Repaglinide Krka 0.5 mg comp. · Repaglinide Krka 1 mg comp. · Repaglinide Krka 2 mg comp. · Repaglinide Teva 0.5 mg comp. · Repaglinide Teva 1 mg comp. · Repaglinide Teva 2 mg comp. 
Enyglid 0,5 mg comprimidos EFG · Enyglid 1 mg comprimidos EFG · Enyglid 2 mg comprimidos EFG · NOVONORM 0,5 mg, COMPRIMIDOS · NOVONORM 1 mg, COMPRIMIDOS · NOVONORM 2 mg, COMPRIMIDOS · PRANDIN 0,5 mg, COMPRIMIDOS · PRANDIN 1 mg, COMPRIMIDOS · PRANDIN 2 mg, COMPRIMIDOS · Repaglinida · Repaglinida Accord 1 mg comprimidos EFG · Repaglinida Accord 2 mg comprimidos EFG · REPAGLINIDA ALTER 1 mg COMPRIMIDOS EFG · REPAGLINIDA ALTER 2 mg COMPRIMIDOS EFG · REPAGLINIDA APOTEX 0,5 mg COMPRIMIDOS EFG · REPAGLINIDA APOTEX 1 mg COMPRIMIDOS EFG · Repaglinida Aurobindo 0,5 mg Comprimidos efg · Repaglinida Aurobindo 2 mg Comprimidos efg · Repaglinida Aurovitas 0,5 mg Comprimidos efg · Repaglinida Aurovitas 1 mg Comprimidos efg · Repaglinida Aurovitas 2 mg Comprimidos efg · REPAGLINIDA AUROVITAS SPAIN 0,5 mg COMPRIMIDOS EFG · REPAGLINIDA AUROVITAS SPAIN 1 mg COMPRIMIDOS EFG · REPAGLINIDA CINFA 0,5 mg COMPRIMIDOS EFG · REPAGLINIDA CINFA 1 mg COMPRIMIDOS EFG · REPAGLINIDA CINFA 2 mg COMPRIMIDOS EFG · REPAGLINIDA COMBIX 1 mg COMPRIMIDOS EFG · REPAGLINIDA COMBIX 2 mg COMPRIMIDOS EFG · REPAGLINIDA EDIGEN 0,5 mg COMPRIMIDOS EFG · REPAGLINIDA EDIGEN 1 mg COMPRIMIDOS EFG · REPAGLINIDA EDIGEN 2 mg COMPRIMIDOS EFG · REPAGLINIDA KERN PHARMA 0,5 mg COMPRIMIDOS EFG · REPAGLINIDA KERN PHARMA 1 mg COMPRIMIDOS EFG · REPAGLINIDA KERN PHARMA 2 mg COMPRIMIDOS EFG · Repaglinida Krka 0,5 mg comprimidos EFG · Repaglinida Krka 1 mg comprimidos EFG · Repaglinida Krka 2 mg comprimidos EFG · REPAGLINIDA NORMON 1 mg COMPRIMIDOS EFG · REPAGLINIDA NORMON 2 mg COMPRIMIDOS EFG · REPAGLINIDA PENSA 0,5 mg COMPRIMIDOS EFG · REPAGLINIDA PENSA 2 mg COMPRIMIDOS EFG · REPAGLINIDA RATIOPHARM 1 mg COMPRIMIDOS EFG · REPAGLINIDA RATIOPHARM 2 mg COMPRIMIDOS EFG · REPAGLINIDA SANDOZ 0,5 mg COMPRIMIDOS EFG · REPAGLINIDA SANDOZ 1 mg COMPRIMIDOS EFG · REPAGLINIDA SANDOZ 2 mg COMPRIMIDOS EFG · REPAGLINIDA STADA 0,5 mg COMPRIMIDOS EFG · REPAGLINIDA STADA 1 mg COMPRIMIDOS EFG · REPAGLINIDA STADA 2 mg COMPRIMIDOS EFG · Repaglinida Tarbis 0,5 mg Comprimidos efg · Repaglinida Tarbis 1 mg Comprimidos efg · Repaglinida Tarbis 2 mg Comprimidos efg · REPAGLINIDA TEVA 1 mg COMPRIMIDOS EFG · REPAGLINIDA TEVA 2 mg COMPRIMIDOS EFG · Repaglinida Viatris 0,50 mg Comprimidos efg · Repaglinida Viatris 1 mg Comprimidos efg 
Glicam · Novonorm · Repaglinide · Theroflan 
RENEOS 0,5 mg · RENEOS 1 mg · RENEOS 2 mg · REPAGLINIDA ARENA 0,5 mg · REPAGLINIDA ARENA 1 mg · REPAGLINIDA ARENA 2 mg · REPAGLINIDA HF 0,5mg · REPAGLINIDA HF 1 mg · REPAGLINIDA HF 2 mg · REPAGLINIDA HF 4 mg 
Enyglid · NovoNorm · Prandin · Repaglinide 
Enyglid · NovoNorm · Prandin · Repaglinid Doc Generici · Repaglinid Teva · Repaglinide Accord · Repaglinide Krka 
NovoNorm · Repaglinide Accord 
Enyglid · NovoNorm · Prandin · Repaglinide Accord · Repaglinide Krka · Repaglinide Teva 
Enyglid-0,5 · Enyglid-1 · Enyglid-2 · Novonorm-0,5 · Novonorm-1 · Novonorm-2 · Prandin-0,5 · Prandin-1 · Prandin-2 · Repaglinide EG · Repaglinide Krka 
Enyglid · NovoNorm · Prandin · Repaglinide Accord · Repaglinide Krka · Repaglinide Teva 
Enyglid · Novonorm · Prandin · Repaglinid Stada · Repaglinide Accord · Repaglinide Krka · Repaglinide Teva 
Enyglid · NovoNorm · Prandin · Repaglinide Accord · Repaglinide ELVIM · Repaglinide Krka · Repaglinide Teva 
Glukoglinid
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