Monograph
A04AA05 - Palonosetron |
Propably not porphyrinogenic |
PNP |
Rationale
Substrate of Cyps 2D6, 3A4 and 1A2. Water soluble drug, thus probably devoid of capacity for significant PXR-activation and subsequent Cyp-induction. Demonstrated in vitro not to be a Cyp-inhibitor or Cyp-inducer. The common side effect of constipation may worsen pre-existing porphyria-induced constipation in the patient.
Chemical description
Quinuclinidinyl-benz-isokinoline. Two cyclic tertiary amine functions in the molecule.
Therapeutic characteristics
Palonosetron is used for prevention of nausea in chemotherapy. It is a potent selective 5-HT receptor antagonist inhibiting reflexogenic nausea caused by 5-OH tryptamine.
Confounding side effects: constipation, diarrhoea.
Metabolism and pharmacokinetics
Metabolized mainly by Cyp 2D6, and to a minor extent by Cyp 3A4 and 1A2. In-vitro studies demonstrate abscence of capacity for Cyp-inhibition or induction.
Similar drugs
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Aloxi 0,25 mg/5 ml, oplossing voor injectie · Aloxi, 500 micrograms capsules, zacht · Palonosetron Accord 250 microgram oplossing voor injectie · Palonosetron Fresenius Kabi 250 microgram, oplossing voor injectie · Palonosetron Fresenius Kabi 250 microgram, oplossing voor injectie in een voorgevulde spuit 
Aloxi · Aloxi 250 ?g sol. inj. i.v. flac. · Aloxi 500 ?g caps. molle · Palonosetron · Palonosetron Accord 250 ?g sol. inj. i.v. flac. · Palonosetron Fresenius Kabi 250 ?g sol. inj. i.v. flac. · Palonosetron Fresenius Kabi 250 ?g sol. inj. i.v. ser. pr?remplie · Palonosetron Juta 250 ?g sol. inj. i.v. flac. 
ALOXI 250 microgramos SOLUCION INYECTABLE · Ferant 250 Microgramos Solucion Inyectable efg · Palonosetron Accord 250 Microgramos Solucion Inyectable efg · Palonosetron Altan 250 Microgramos Solucion Inyectable efg · Palonosetron Fresenius Kabi 250 Mcrogramos Solucion Inyectable efg · Palonosetron Fresenius Kabi 250 Microgramos Solucion Inyectable en Jeringa Precargada · Palonosetron Kalceks 250 Microgramos Solucion Inyectable efg · Palonosetron Qilu 250 Microgramos Solucion Inyectable efg · Palonosetron Sala 250 Microgramos Solucion Inyectable efg 
Aloxi · FERANT 250 micrograme · PALONOSETRON ACCORD 250 micrograme · PALONOSETRON DR. REDDY'S 250 micrograme · PALONOSETRON FRESENIUS KABI 250 micrograme · PALONOSETRON KALCEKS 250 micrograme · PALONOSETRON STADA 250 micrograme 
Aloxi · Palonosetron 
Aloxi · Palonosetron Accord · Palonosetron Macure · Palonosetron Reig Jofre · Palonosetron Stada · Palonosetronhydrochlorid Qilu 
Aloxi · Palonosetron Accord · Palonosetron Fresenius Kabi · Palonossetrom fresenius kabi 
Aloxi · Palonosetron · Palonosetron Accord 
Aloxi · Aloxi 500mcg · Palonosetron Accord 
Aloxi · Palonosetron Accord 
Aloxi · Palonosetron Accord · Palonosetron Fresenius Kabi · Palonosetron Macure · Palonosetron Reig Jofre · Palonosetron Stada 
Aloxi · Ferant · Palonosetron Accord · Palonosetron Kalceks 
Aloxi® · Ferant® · Palo Sala · Palonosetron Accord · Palonosetron Fresenius Kabi
© NAPOS 2025