Monograph
A10BD07 - Metformin and Sitagliptin |
Propably not porphyrinogenic |
PNP |
Rationale
Neither metformin nor sitagliptin have the potential to inhibit or induce CYP enzymes. No porphyrinogenic physiological effects. Vomiting and loss of appetite is potentially porphyrogenic side effects through interference with nutrition and motivates attendance.
Therapeutic characteristics
Metformin and sitagliptin is indicated for the improvement of glycaemic control in adult patients with type 2 diabetes mellitus. Vomiting and loss of appetite is potentially porphyrogenic side effects through interference with nutrition intake.
Metabolism and pharmacokinetics
Metformin: Not a Cyp-substrate. Sitagliptin: Approximately 79 per cent of sitagliptin is excreted unchanged in the urine.
Nonclinical studies indicate that the small portion of sitagliptin that undergoes biotransformation is metabolized by Cyp3A4 with the help of Cyp2C8.
In vitro data has shown that sitagliptin is not an inhibitor of CYP isozymes CYP3A4, 2C8, 2C9, 2D6, 1A2, 2C19 or 2B6, and is not an inducer of CYP3A4 and CYP1A2Experiental and clinical data indicate that there is low risk for pharmacokinetic interactions with Cyp-metabolized drugs.
IPNet drug reports
Metformin (ATC code: A10BA02) 30 reports of uneventful use. Sitagliptin: No EPNET drug reports.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Pharmacokinetics of dipeptidylpeptidase-4 inhibitors.
Scheen AJ. Diabetes Obes Metab. 2010 Aug; 12(8):648-58. |
20590741 |
| 2. | Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications.
Tornio A, Niemi M, et al. Trends Pharmacol Sci. 2012 Jun;33(6):312-22. |
22475684 |
| * | Summary of Product Characteristics | |
| 3. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Janumet.
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| * | Other sources | |
| 4. | See also the monographs of metformin (ATC A10BA02) and of sitagliptin (ATC A10BH01).
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Efficib 50 mg/1000 mg, filmomhulde tabletten · Efficib 50 mg/850 mg, filmomhulde tabletten · Eprocliv 50/1000 mg, filmomhulde tabletten · Eprocliv 50/850 mg, filmomhulde tabletten · Fordiab 50 mg/1000 mg filmomhulde tabletten · Fordiab 50 mg/850 mg filmomhulde tabletten · JANECLUC 50 mg/1000 mg filmomhulde tabletten · JANECLUC 50 mg/850 mg filmomhulde tabletten · Janumet 50/1000 · Janumet 50/850 · Metformin / Sitagliptin · Ristfor 50 mg/1000 mg, filmomhulde tabletten · Ristfor 50 mg/850 mg, filmomhulde tabletten · Sademlip 50/1000 mg, filmomhulde tabletten · Sademlip 50/850 mg, filmomhulde tabletten · Simevin 50 mg/1000 mg filmomhulde tabletten · Simevin 50 mg/850 mg filmomhulde tabletten · Sipactimet 50mg/1000 mg, filmomhulde tabletten · Sipactimet 50mg/850 mg, filmomhulde tabletten · Sitaglazamet 50 mg/1000 mg filmomhulde tabletten · Sitaglazamet 50 mg/850 mg filmomhulde tabletten · Velmetia 50/1000 mg · Velmetia 50/850 mg 
Efficib 50 mg - 1 000 mg compr. pellic. · Efficib 50 mg - 850 mg compr. pellic. · Janumet 50 mg - 1 000 mg compr. pellic. · Janumet 50 mg - 850 mg compr. pellic. · Metformin / Sitagliptin · Velmetia 50 mg - 1 000 mg compr. pellic. · Velmetia 50 mg - 850 mg compr. pellic. 
Disimet 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · EFFICIB 50 mg/1000 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Eprocliv 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Eprocliv 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Estequen · Estequen 100 mg/1.000 mg Comprimidos de Liberacion Modificada · Jamesi 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Jamesi 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Janumet 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula · Janumet 50 mg/1000 mg Comprimidos Recubiertos con Pelicula · Jivolar · Metsunix 100 mg/1.000 mg Comprimidos de Liberacion Modificada · Metsunix 50 mg/1.000 mg Comprimidos de Liberacion Modificada · Metsunix 50 mg/500 mg Comprimidos de Liberacion Modificada · Ristfor 50 mg/1000 mg Comprimidos Recubiertos con Pelicula · RISTFOR 50mg/1000 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Sitagliptina/Hidrocloruro de Metformina sun 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Hidrocloruro de Metformina sun 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Adair 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Almus 50 mg /1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Almus 50 mg/ 850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Alter 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Aurovitas Spain 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Cinfalab 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Cinfalab 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Cinfamed 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Combix 50mg/1000mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Combix 50mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina dr Reddys 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina dr Reddys 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Grindeks 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Grindeks 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Kern Pharma 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Krka 50 mg/1000 mg Comprimidos Recubiertos de Pelicula efg · Sitagliptina/Metformina Krka 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Merck 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Merck 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Mylan 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Normon 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Opko 50 mg/1.000 mg Comprimidos Recubiertos con pel?Cula efg · Sitagliptina/Metformina Opko 50 mg/850 mg Comprimidos Recubiertos con pel?Cula efg · Sitagliptina/Metformina Pensa 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Pharmathen 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Pharmathen 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Ratiopharm 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Sandoz 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Sandoz 50 mg/850 mg Comprimidos Recubiertos con pel?Cula efg · Sitagliptina/Metformina Sandoz Farmaceutica 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Sandoz Farmaceutica 50mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Stada 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Stada 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Swanpond Investments 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Swanpond Investments 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Tecnigen 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Tecnigen 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Tecnimede 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Teva 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Viso Farmaceutica 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Sitagliptina/Metformina Viso Farmaceutica 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Velmetia 50 mg/1000 mg Comprimidos Recubiertos con Pelicula 
Diesmit · Efficib · Janumet · Metformin / Sitagliptin · Velmetia 
EPROCLIV 50 mg/1000 mg · JAMESI 50 mg/1000 mg · JAMESI 50 mg/850 mg · JAMESI NOVUM 50 mg/1000 mg · JANSITIN DUO 50 mg/1000 mg · JANSITIN DUO 50 mg/850 mg · JANUMET 50 mg/1000 mg · JIVOLAR 50 mg/1000 mg · JIVOLAR 50 mg/850 mg · JUZIMETTE 50 mg/1000 mg · JUZIMETTE 50 mg/850 mg · LONAMO DUO 50 mg/1000 mg · LONAMO DUO 50 mg/850 mg · MAYMETSI 50 mg/1000 mg · MAYMETSI 50 mg/850 mg · Metformin / Sitagliptin · METLINKA 50 mg/1000 mg · METLINKA 50 mg/850 mg 
Janumet · Metformin / Sitagliptin 
Efficib · Glerova · Janumet · Metformin / Sitagliptin · Ristfor · Velmetia 
Janumet · Metformin / Sitagliptin 
Ansifora Duo · Asigefort · Asitalip Combo · Co-Fineria · Combodiab · Depepsit Met · Efficib · Eprocliv · Fordiab · Jamesi · Jamesi Novum · Jansitin Duo · Janumet · Juzimette · Lonamo Duo · Maymetsi · Metformax Combi · Metformax SR Combi · Metformin / Sitagliptin · Metsigletic · Mifomet · Ristfor · Sademlip · Sitaformil duo · Symetlip · Sytagliptyna + Metforminy chlorowodorek Reddy · Sytena Plus · Velmetia 
Efficib-50/1000 · Efficib-50/850 · Janumet-50/1000 · Janumet-50/850 · Metformin / Sitagliptin · Ristfor · Velmetia-50/1000 · Velmetia-50/850 
Efficib · Janumet · Metformin / Sitagliptin · Ristfor · Velmetia 
Brandasit · Efficib · Janumet · Metformin / Sitagliptin · Ristfor · Velmetia 
Asigefort · Efficib · Eprocliv · Jamesi · Jansitin Duo · Janumet · Jivolar · Juzimette · Maymetsi · Metformin / Sitagliptin · Ristfor · Tixulda · Velmetia 
Dolista® Duo · Eprocliv · Fordiabik® Combo · Janumet® · Maymetsi® · Vidiasin
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