Monograph
A10BH02 - Vildagliptin |
Propably not porphyrinogenic |
PNP |
Rationale
Vildagliptin is not a CYP substrate and has no capacity for inhibition or induction of the major CYP-subclasses. There are no pharmacokinetic drug interactions with vildagliptin as perpetrator.
Chemical description
Hydroxy admantan amino acetyl pyrrolidine carbonitrile
Therapeutic characteristics
Vildagliptin is indicated for the improvement of glycaemic control in adult patients with type 2 diabetes mellitus. It can be used as mono therapy or as part of combination therapy with other anti-diabetic drugs.
Vildagliptin increases the levels of endogenous incretin hormones via potent and selective inhibition of dipeptidyldipeptidase-4 (DPP-4). Nausea is a common side effect of vildagliptin that may potentially be porphyrinogenic through reduction in carbohydrate intake.
Metabolism and pharmacokinetics
Vildagliptin is not a CYP substrate; it is metabolized by hydrolysis mainly in the kidneys. It is devoid of capacities for induction or inhibition of any of the CYP-subclasses. There are no pharmacokinetic interactions with vildagliptin as perpetrator.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors.
Golightly LK, Drayna CC, et al. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14. |
|
| 2. | Clinical pharmacokinetics and pharmacodynamics of vildagliptin.
He YL. Clin Pharmacokinet. 2012 Mar 1;51(3):147-62. |
22339447 |
| 3. | Pharmacokinetics of dipeptidylpeptidase-4 inhibitors.
Scheen AJ. Diabetes Obes Metab. 2010 Aug; 12(8):648-58. |
20590741 |
| * | Summary of Product Characteristics | |
| 4. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Galvus.
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
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Galvus 50 mg tabletten, tabletten · Jalra 50 mg, tabletten · Vildagliptine Accord 50 mg tabletten · Vildagliptine Amarox 50 mg tabletten · Vildagliptine Denk 50 mg tabletten · Vildagliptine Intas 50 mg tabletten · Vildagliptine Macleods 50 mg tabletten · Xiliarx 50 mg, tabletten 
Galvus 50 mg comp. · Jalra 50 mg comp. · Vildagliptin Krka 50 mg comp. · Xiliarx 50 mg comp. 
GALVUS 50 mg COMPRIMIDOS · Glypvilo 50 mg Comprimidos efg · JALRA 50 mg COMPRIMIDOS · Vildagliptina · Vildagliptina Alter 50 mg Comprimidos efg · Vildagliptina Aurovitas 50 mg Comprimidos efg · Vildagliptina Cinfa 50 mg Comprimidos efg · Vildagliptina Combix 50 mg Comprimidos efg · Vildagliptina Diagonalis 50 mg Comprimidos efg · Vildagliptina Kern Pharma 50 mg Comprimidos efg · Vildagliptina Normon 50 mg Comprimidos efg · Vildagliptina Olpha 50 mg Comprimidos efg · Vildagliptina Pensa 50 mg Comprimidos efg · Vildagliptina Sandoz 50 mg Comprimidos efg · Vildagliptina Swanpond Investments 50 mg Comprimidos efg · Vildagliptina Tarbis 50 mg Comprimidos efg · Vildagliptina Tecnigen 50 mg Capsulas Duras efg · Vildagliptina Viatris 50 mg Comprimidos efg · Vildagliptina vir 50 mg Comprimidos efg · XILIARX 50 mg COMPRIMIDOS 
Galvus · Vildagliptin 
AGARTHA 50 mg · DALMEVIN 50 mg · GALVUS 50 mg · GLUADDA 50 mg · GLYPVILO 50 mg · MELKART 50 mg · TIOTROPIU MYLAN 18 micrograme 
Galvus · Vildagliptin 
Galvus · Jalra · Vildagliptin Accord · Vildagliptin AET · Vildagliptin Axunio · Vildagliptin Krka · Vildagliptin Mylan · Vildagliptin Pharmathen · Vildagliptin Stada · Vildagliptin Teva · Vildagliptin Tiefenbacher · Xiliarx 
Galvus · Vildagliptin Accord · Vildagliptin Krka 
Agartha · Agnis · Alikval · Anvildis · Diptivil · Galvus · Gluadda · Glypvilo · Jalra · Kwikaton · Melkart · Pernuvi · Viglita · Xiliarx 
Galvus · Jalra · Xiliarx 
Galvus · Jalra · Vildagliptin STADA · Xiliarx 
Galvus · Jalra · Vildagliptin Accord · Vildagliptin Krka · Vildagliptin ratiopharm · Vildagliptin STADA · Xiliarx 
Dalmevin · Galvus · Glypvilo · Jalra · Saxotin · Vildagliptin Unifarma · Xiliarx 
Agnis® · Criteo® · Glypvilo® · Taglin®
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