Monograph
J02AX06 - Anidulafungin |
Propably not porphyrinogenic |
PNP |
Important Information
Risk for gastrointestinal adverse events in the form of diarrhoea, vomiting and nausea motivates vigilance against insufficient intake of food, especially of carbohydrate.
Side effects
Very common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are diarrhoea, vomiting and nausea.
Other common side effects are increased levels of alanine aminotransferase and aspartate aminotransferase.
Rationale
Anidulafungin is not a substrate, inducer or inhibitor of CYP enzymes.
Therapeutic characteristics
Anidulafungin is indicated for the treatment of invasive candidiasis in adult non-neutropenic patients.
Metabolism and pharmacokinetics
Anidulafungin is not metabolised in the liver (SPC). In vitro studies showed that the primary biotransformation of anidulafungin is mediated by slow chemical degradation. It is thought that anidulafungin and its degradation products are exclusively eliminated via biliary excretion (Damle 2009).
It is not a clinically relevant substrate, inducer or inhibitor of CYP450 isoenzymes (Damle 2009 and SPC).
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | In vitro and in vivo studies to characterize the clearance mechanism and potential cytochrome P450 interactions of anidulafungin.
Damle BD, Dowell JA et al. Antimicrob Agents Chemother. 2009 Mar;53(3):1149-56. |
19029327 |
| * | Summary of Product Characteristics | |
| 2. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Anidulafungin. Last edition: date not listed.
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
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Anidulafungine Accord 100 mg poeder voor concentraat voor oplossing voor infusie · Anidulafungine CF 100 mg, poeder voor concentraat voor oplossing voor intraveneuze infusie · Anidulafungine Teva 100 mg, poeder voor concentraat voor oplossing voor intraveneuze infusie · Ecalta 100 mg, poeder voor concentraat voor oplossing voor intraveneuze infusie 
Anidulafungin · Anidulafungin Sandoz 100 mg sol. perf. (pdr., ? diluer) i.v. flac. · Anidulafungine · Anidulafungine Accord Healthcare 100 mg sol. perf. (pdr., ? diluer) i.v. flac. · Ecalta · Ecalta 100 mg sol. perf. (pdr., ? diluer) i.v. flac. 
Anidulafungina · Anidulafungina Accord 100 mg Polvo Para Concentrado Para Solucion Para Perfusion efg · Anidulafungina Diamed 100 mg Polvo Para Concentrado Para Solucion Para Perfusion efg · Anidulafungina Fresenius Kabi 100 mg Polvo Para Concentrado Para Solucion Para Perfusi?n efg · Anidulafungina Mylan 100 mg Polvo Para Concentrado Para Solucion Para Perfusion efg · Anidulafungina Normogen 100 mg Polvo Para Concentrado Para Solucion Para Perfusion efg · Anidulafungina Reig Jofre 100 mg Polvo Para Concentrado Para Solucion Para Perfusion efg · Anidulafungina Stada 100 mg Polvo Para Concentrado Para Solucion Para Perfusion efg · Anidulafungina Swanpond Investments 100 mg Polvo Para Concentrado Para Solucion Para Perfusion efg · Anidulafungina Teva 100 mg Polvo Para Concentrado Para Solucion Para Perfusion efg · ECALTA 100 mg POLVO PARA CONCENTRADO PARA SOLUCION PARA PERFUSION 
ANIDULAFUNGINA ACCORD 100 mg · ANIDULAFUNGINA ROMPHARM 100 mg · ANIDULAFUNGINA TEVA 100 mg · ECALTA 100mg 
Anidulafungin · Ecalta 
Anidulafungin Accord · Anidulafungin Reig Jofre · Anidulafungin Sandoz · Anidulafungin Stada · Ecalta 
Anidulafungin Accord · Anidulafungin Reig Jofre · Ecalta 
Anidulafungin Fresenius Kabi · Anidulafungin Mylan · Anidulafungin Sandoz · Anidulafungin Synoptis · Anidulafungina Accord · Ecalta 
Anidulafungine EG · Ecalta 
Anidulafungin Normon · Ecalta 
Anidulafungin Accord · Anidulafungin Reig Jofre · Anidulafungin Stada · Ecalta 
Ecalta 
Anidulafungin Pliva · Ecalta®
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