Monograph
M04AA03 - Febuxostat |
Propably not porphyrinogenic |
PNP |
Rationale
Febuxostat is a substrate of CYP 1A1, 1A2, 2C8 and 2C9, but it has not shown potential for significant induction or inhibition of CYP enzymes. No potentially porphyrinogenic pharmacokinetic properties are suspected.
Chemical description
Febuxostat is a thiazole derivative and inhibitor of xanthine oxidase.
Therapeutic characteristics
Febuxostat is used in the treatment of chronic hyperuricaemia. It is administered orally and has a half-life of approximately 5 to 8 hours.
Metabolism and pharmacokinetics
The metabolism of febuxostat includes oxidation by CYP1A1, CYP1A2, CYP2C8 or CYP2C9 into at least three active metabolites. (SPC, Adenuric)
In an in vitro study of potential drug-drug interactions including testing for possible interactions with CYP1A1, 2C9, 2C19, 2D6, and 3A4, only weak inhibition of CYP 2D6 was shown (Mukoyoshi 2008).
According to the SPC, in vitro studies have shown potential for CYP 2C8 and 2D6 inhibition. In vivo studies found no effect on CYP 2C8 and only negligible inhibition of CYP 2D6.
No potential CYP interactions are listed in drug-drug- interaction databases. (Lexi-interact, NOMA, The Danish Health and Medicines Authority).
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition.
Mukoyoshi M, Nishimura S et al. Xenobiotica. 2008 May;38(5):496-510. |
18421623 |
| * | Government bodies | |
| 2. | Norwegian medicines agency (NOMA). Find medicine.
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| * | Drug interaction databases | |
| 3. | Lexi-Interact, via UpToDate.
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| 4. | The Danish Health and Medicines Authority. The drug interaction database.
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| * | Summary of Product Characteristics | |
| 5. | European Medicines Agency, SPC Adenuric (
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
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Adenuric 120 mg, filmomhulde tabletten · Adenuric 80 mg, filmomhulde tabletten · Feburik 80 mg, omhulde tabletten · Febuxostat · Febuxostat Accord 120 mg, filmomhulde tabletten · Febuxostat Accord 80 mg, filmomhulde tabletten · Febuxostat Krka 120 mg, filmomhulde tablet · Febuxostat Krka 80 mg, filmomhulde tablet · Febuxostat Laboratorios Liconsa 120 mg filmomhulde tabletten · Febuxostat Laboratorios Liconsa 80 mg filmomhulde tabletten · Febuxostat Liconsa 120 mg filmomhulde tabletten · Febuxostat Liconsa 80 mg filmomhulde tabletten · Febuxostat Teva 120 mg, filmomhulde tabletten · Febuxostat Teva 80 mg, filmomhulde tabletten · Febuxostat Viatris 120 mg, filmomhulde tabletten · Febuxostat Viatris 80 mg, filmomhulde tabletten · Febuxostat Vivanta 120 mg filmomhulde tabletten · Febuxostat Vivanta 80 mg filmomhulde tabletten · Febuxostat Xiromed 120 mg filmomhulde tabletten · Febuxostat Xiromed 80 mg filmomhulde tabletten 
Adenuric 120 mg compr. pellic. · Adenuric 80 mg compr. pellic. · Feburik 80 mg compr. enr. · Febuxostat AB 120 mg compr. pellic. · Febuxostat AB 80 mg compr. pellic. · Febuxostat EG 120 mg compr. pellic. · Febuxostat EG 80 mg compr. pellic. · Febuxostat Krka 120 mg compr. pellic. · Febuxostat Krka 80 mg compr. pellic. · Febuxostat Sandoz 120 mg compr. pellic. · Febuxostat Sandoz 80 mg compr. pellic. · Febuxostat Viatris 120 mg compr. pellic. · Febuxostat Viatris 80 mg compr. pellic. 
Adenuric 120 mg Comprimidos Recubiertos con Pelicula · Adenuric 80 mg Comprimidos Recubiertos con Pelicula · Febuxostat · Febuxostat Accord 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Accord 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Aristo 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Aurobindo 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Aurovitas 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Aurovitas 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Bluepharma 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Bluepharma 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Cinfa 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Cinfa 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Cinfamed 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Cinfamed 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Combix 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Combix 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Kern Pharma 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Kern Pharma 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Krka 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Krka 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Liconsa 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Liconsa 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Mabo 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Mabo 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Normon 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Normon 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Pharma Combix 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Ratiopharm 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Sandoz 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Sandoz 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Stada 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Stada 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Tecnigen 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Teva-Ratiopharm 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Teva-Ratiopharm 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat vir 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat vir 80 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Viso Farmaceutica 120 mg Comprimidos Recubiertos con Pelicula efg · Febuxostat Viso Farmaceutica 80 mg Comprimidos Recubiertos con Pelicula efg · Gotaric 120 mg Comprimidos Recubiertos con Pelicula efg · Gotaric 80 mg Comprimidos Recubiertos con Pelicula efg · Uxaton 120 mg Comprimidos Recubiertos con Pelicula efg · Uxaton 80 mg Comprimidos Recubiertos con Pelicula efg 
Adenuric · Alphabux · Arbux · Dymauric · Febuxen · Febuxostat · Gauti · Gottart · Uriquid 
ADENURIC 120mg · ADENURIC 80mg · FEBUXOSTAT KRKA 120 mg · FEBUXOSTAT KRKA 80 mg · FORURE 120 mg · FORURE 80 mg 
Adenuric · Elstabya · Febuxostat 
Adenuric · Elstabya · Febuxostat Accord · Febuxostat Krka · Febuxostat Medical Valley · Febuxostat Teva · Febuxostat Viatris 
Adenuric · Febuxostat Accord · Febuxostat novadoz · Febuxostat sun · Uloric 
Adenuric · Denofix · Febuxostat Accord · Febuxostat Aurovitas · Febuxostat Krka · Febuxostat Laboratorios Liconsa · Febuxostat MSN · Febuxostat Solinea · Febuxostat Viatris · Prohidna 
Adenuric · Feburik · Febuxostat EG · Febuxostat Viatris 
Adenuric · Febuxostat Krka · Febuxostat Medical Valley · Febuxostat Viatris 
Adenuric · Febuxostat Accord · Febuxostat Krka · Febuxostat Viatris 
Adenuric · Denofix · Druniler · Febuxostat Krka · Febuxostat Mylan · Febuxostat Teva · Febuxostat Zentiva 
Abuxar® · Adenuric® · Fitaxyl® · Gutana®
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