Monograph
V03AC03 - Deferasirox |
Propably not porphyrinogenic |
PNP |
Rationale
Only insignificant Cyp metabolism. Interaction studies suggest that deferasirox has an inductive effect on CYP3A4, but this effect is probably too weak to be porphyrinogenic.
Chemical description
Deferasirox is a compound consisting of two hydroxyphenyls and one benzoic acid ring joined by a triazole ring.
Therapeutic characteristics
Deferasirox is an orally active iron chelator used in the treatment of chronic iron overload due to blood transfusions. It is administered orally.
Common adverse reactions of deferasirox that can be confused with an acute porphyric attack are constipation, vomiting, nausea and abdominal pain. Side effects as nausea, vomiting and diarrhoea may be potentially porphyrinogenic through reduction in caloric intake.
Metabolism and pharmacokinetics
Deferasirox is metabolised mainly by glucuronidation at the carboxylate group to acyl glucuronide, and at the phenolic hydroxy groups to 2-O-glucuronides. Oxidative metabolism, probably by Cyp1A and Cyp2D6, are minor, representing only 6% and 2% of the dose, respectively (Waldmeier, 2010). Interaction studies suggest that deferasirox is a weak inhibitor of CYP2C8 and a weak inducer of CYP3A4 (Skerjanec, 2010). Defarasirox has a high degree of plasma albumin binding, and the unbound fraction is less than 2 % (Weiss, 2006).
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Skerjanec, A, Wang, J. et al. Investigation of the Pharmacokinetic Interactions of Deferasirox, a Once-Daily Oral Iron Chelator, With Midazolam, Rifampin, and Repaglinide in Healthy Volunteers.
J Clin Pharmacol. 2010;50(2):205-13. |
|
| 2. | waldmeier, F, et al. Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state.
Drug Metab Dispos. 2010;38(5):808-16. |
|
| 3. | Weiss, H.M., Fresneau, M. et al. In vitro blood distribution and plasma protein binding of the iron chelator deferasirox (ICL670) and its iron complex Fe-[ICL670]2 for rat, marmoset, rabbit, mouse, dog, and human.
Drug Metab Dispos. 2006;34(6):971-5. |
|
| * | Drug reference publications | |
| 4. | Sweetman SC, editor. Martindale: The complete drug reference. Deferasirox. Pharmaceutical Press 2009.
|
|
| * | Government bodies | |
| 5. | European Public Assessment Report, Exjade (Scientific discussion).European Medicines Agency (EMEA). Accessible from: emea.europa.eu
|
|
| * | Summary of Product Characteristics | |
| 6. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Exjade.
|
|
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Deferasirox Abdi 180 mg filmomhulde tabletten · Deferasirox Abdi 360 mg filmomhulde tabletten · Deferasirox Abdi 90 mg filmomhulde tabletten · Deferasirox Accord 180 mg, filmomhulde tabletten · Deferasirox Accord 360 mg, filmomhulde tabletten · Deferasirox Accord 90 mg, filmomhulde tabletten · Deferasirox Amarox 360 mg filmomhulde tabletten · Deferasirox Aurobindo 180 mg, filmomhulde tabletten · Deferasirox Aurobindo 360 mg, filmomhulde tabletten · Deferasirox Aurobindo 90 mg, filmomhulde tabletten · Deferasirox betapharm 180 mg,filmomhulde tabletten · Deferasirox betapharm 360 mg,filmomhulde tabletten · Deferasirox betapharm 90 mg,filmomhulde tabletten · Deferasirox CF 180 mg, filmomhulde tabletten · Deferasirox CF 360 mg, filmomhulde tabletten · Deferasirox CF 90 mg, filmomhulde tabletten · Deferasirox CF 900 mg, filmomhulde tabletten · Deferasirox DOC 180 mg, filmomhulde tabletten · Deferasirox DOC 360 mg, filmomhulde tabletten · Deferasirox DOC 90 mg, filmomhulde tabletten · Deferasirox MSN 180 mg filmomhulde tabletten · Deferasirox MSN 360 mg filmomhulde tabletten · Deferasirox MSN 90 mg filmomhulde tabletten · Deferasirox Mylan 180 mg, filmomhulde tabletten · Deferasirox Mylan 360 mg, filmomhulde tabletten · Deferasirox Mylan 90 mg, filmomhulde tabletten · Deferasirox RAFARM 180 mg, filmomhulde tabletten · Deferasirox RAFARM 360 mg, filmomhulde tabletten · Deferasirox RAFARM 90 mg, filmomhulde tabletten · Deferasirox Sandoz 180 mg, filmomhulde tabletten · Deferasirox Sandoz 360 mg, filmomhulde tabletten · Deferasirox Sandoz 90 mg, filmomhulde tabletten · Deferasirox Stada 180 mg, filmomhulde tabletten · Deferasirox Stada 360 mg, filmomhulde tabletten · Deferasirox Stada 90 mg, filmomhulde tabletten · Deferasirox Stada 900 mg, filmomhulde tabletten · Deferasirox SUN 180 mg filmomhulde tabletten · Deferasirox SUN 360 mg filmomhulde tabletten · Deferasirox SUN 90 mg filmomhulde tabletten · Deferasirox Synthon 180 mg, filmomhulde tabletten · Deferasirox Synthon 360 mg, filmomhulde tabletten · Deferasirox Synthon 90 mg, filmomhulde tabletten · Deferasirox Synthon Hispania 180 mg, filmomhulde tabletten · Deferasirox Synthon Hispania 360 mg, filmomhulde tabletten · Deferasirox Synthon Hispania 90 mg, filmomhulde tabletten · Deferasirox Teva 180 mg, filmomhulde tabletten · Deferasirox Teva 360 mg, filmomhulde tabletten · Deferasirox Teva 90 mg, filmomhulde tabletten · Deferasirox Teva 900 mg, filmomhulde tabletten · Deferasirox Vivanta 180 mg filmomhulde tabletten · Deferasirox Vivanta 360 mg filmomhulde tabletten · Deferasirox Vivanta 90 mg filmomhulde tabletten · Deferasirox Xiromed 180 mg filmomhulde tabletten · Deferasirox Xiromed 360 mg filmomhulde tabletten · Deferasirox Xiromed 90 mg filmomhulde tabletten · Exferana 180 mg, filmomhulde tabletten · Exferana 360 mg, filmomhulde tabletten · Exjade 180 mg, filmomhulde tabletten · Exjade 180 mg, granules · Exjade 360 mg, filmomhulde tabletten · Exjade 360 mg, granules · Exjade 90 mg, filmomhulde tabletten · Exjade 90 mg, granules · SIDIPAST 180 mg, filmomhulde tabletten · SIDIPAST 360 mg, filmomhulde tabletten · SIDIPAST 90 mg, filmomhulde tabletten 
Deferasirox AB 180 mg compr. pellic. · Deferasirox AB 360 mg compr. pellic. · Deferasirox AB 90 mg compr. pellic. · Deferasirox Accord 180 mg compr. pellic. · Deferasirox Accord 360 mg compr. pellic. · Deferasirox Accord 90 mg compr. pellic. · Deferasirox Mylan 180 mg compr. pellic. · Deferasirox Mylan 360 mg compr. pellic. · Deferasirox Mylan 90 mg compr. pellic. · Deferasirox Pharmathen 180 mg compr. pellic. · Deferasirox Pharmathen 360 mg compr. pellic. · Deferasirox Pharmathen 90 mg compr. pellic. · Exjade 180 mg compr. pellic. · Exjade 180 mg gran. sachet · Exjade 360 mg compr. pellic. · Exjade 360 mg gran. sachet · Exjade 90 mg compr. pellic. · Exjade 90 mg gran. sachet 
Deferasirox · Deferasirox Abdi 180 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Abdi 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Accord 180 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Accord 360 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Accord 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Alembic 360 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Alembic 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Aurovitas 360 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Aurovitas 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Pharmathen 180 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Pharmathen 360 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Ratiopharm 360 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Ratiopharm 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Stada 180 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Stada 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox sun 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Tarbis 360 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Teva 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Umedica 180 mg Comprimidos Recubiertos con pel?Cula efg · Deferasirox Umedica 360 mg Comprimidos Recubiertos con pel?Cula efg · Deferasirox Umedica 90 mg Comprimidos Recubiertos con pel?Cula efg · Deferasirox Viso Farmaceutica 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Vivanta 180 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Vivanta 90 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Zentiva 180 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Zentiva 360 mg Comprimidos Recubiertos con Pelicula efg · Deferasirox Zentiva 90 mg Comprimidos Recubiertos con Pelicula efg · Exjade · Exjade 125 mg Comprimidos Dispersables · Exjade 360 mg Comprimidos Recubiertos con Pelicula · Exjade 90 mg Comprimidos Recubiertos con Pelicula · Ferupantil 360 mg Comprimidos Recubiertos con Pelicula efg · Ferupantil 90 mg Comprimidos Recubiertos con Pelicula efg 
Deferasirox · Exjade 
DEFERASIROX ACCORD 180 mg · DEFERASIROX ACCORD 360 mg · DEFERASIROX MSN LABORATORIES 180 mg · DEFERASIROX MSN LABORATORIES 360 mg · DEFERASIROX MSN LABORATORIES 90 mg · DEFERASIROX STADA 180 mg · DEFERASIROX STADA 360 mg · DEFERASIROX STADA 90 mg · DEFLOXOL 180 mg · DEFLOXOL 360 mg · DEFLOXOL 90 mg · EXJADE 125mg · EXJADE 180 mg · EXJADE 250mg · EXJADE 360 mg · EXJADE 500mg · REDITENS 180 mg · REDITENS 360 mg · REDITENS 90 mg · ZEOKS 180 mg · ZEOKS 360 mg 
Deferasirox · Exjade 
Deferasirox Accord · Deferasirox Glenmark · Deferasirox Jubilant · Deferasirox Medical Valley · Deferasirox Mylan · Deferasirox Orifarm · Deferasirox Pharmathen · Deferasirox Sandoz · Deferasirox Sigillata · Deferasirox Stada · Deferasirox Teva · Defloxol · Exjade 
Deferasirox Accord · Deferasirox Sandoz · Exjade 
Deferasirox Accord · Deferasirox MSN · Deferasirox Mylan · Exferana · Exjade 
Deferasirox Accord · Exjade 
Deferasirox Accord · Deferasirox Medical Valley · Deferasirox Mylan · Exjade · Zeoks 
Deferasirox Accord · Deferasirox Glenmark · Deferasirox Mylan · Deferasirox Orifarm · Deferasirox Stada · Exjade 
Deferasirox Accord · Deferasirox Mylan · Deferasirox Umedica · Exjade 
Exjade®
© NAPOS 2025