Monograph
N02AX06 - Tapentadol |
Propably not porphyrinogenic |
PNP |
Rationale
Studies have shown that tapentadol has no clinically relevant potential for induction or inhibition of CYP enzymes and is therefore probably not porphyrinogenic. Side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Chemical description
Tapentadol is an μ-opioid agonist with noradrenaline reuptake inhibiting properties.
Therapeutic characteristics
Tapentadol is an analgesic used for the relief of moderate to severe acute pain in adults.
It is administered orally.
Common adverse reactions of tapentadol that can be confused with an acute porphyric attack are nausea, vomiting and constipation. Side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Metabolism and pharmacokinetics
Tapentadol is mainly metabolized by conjugation with glucuronic acid to produce glucuronides. A smaller portion of the drug is metabolized to N-desmethyl tapentadol (13%) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (2%) by CYP2D6, which are further metabolized by conjugation.
In vitro studies has not revealed any clinical significant potential of tapentadol to either inhibit or induce cytochrome P450 enzymes. One in vitro study showed inhibition of CYP 2D6 to a limited extent, but at clinically irrelevant concentrations.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes.
Kneip C, Terlinden R et al. Drug Metab Lett. 2008 Jan;2(1):67-75. |
19356073 |
| 2. | Tapentadol: an initial analysis.
Prommer EE. J Opioid Manag. 2010 May-Jun;6(3):223-6. |
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| * | Drug reference publications | |
| 3. | Sweetman SC, editor. Martindale: The complete drug reference. Tapentadol. Pharmaceutical Press 2009.
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| * | Government bodies | |
| 4. | Food and Drug Administration. FDA labelling information. FDA web site,
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| * | Summary of Product Characteristics | |
| 5. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). (Palexia).
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Dolten 100 mg filmomhulde tabletten · Dolten 50 mg filmomhulde tabletten · Dolten 75 mg filmomhulde tabletten · Dolten retard 100 mg tabletten met verlengde afgifte · Dolten retard 150 mg tabletten met verlengde afgifte · Dolten retard 50 mg tabletten met verlengde afgifte · Palexia 100 mg, filmomhulde tabletten · Palexia 20 mg/ml drank · Palexia 4 mg/ml drank · Palexia 50 mg, filmomhulde tabletten · Palexia 75 mg, filmomhulde tabletten · Palexia Retard 100 mg tabletten met verlengde afgifte · Palexia Retard 150 mg tabletten met verlengde afgifte · Palexia Retard 200 mg tabletten met verlengde afgifte · Palexia Retard 25 mg, tabletten met verlengde afgifte · Palexia Retard 250 mg tabletten met verlengde afgifte · Palexia Retard 50 mg tabletten met verlengde afgifte · Tapentadol Consilient Health 100 mg filmomhulde tabletten · Tapentadol Consilient Health 50 mg filmomhulde tabletten · Tapentadol Consilient Health 75 mg filmomhulde tabletten · Tapentadol retard CF 100 mg, tabletten met verlengde afgifte · Tapentadol retard CF 150 mg, tabletten met verlengde afgifte · Tapentadol retard CF 200 mg, tabletten met verlengde afgifte · Tapentadol retard CF 25 mg, tabletten met verlengde afgifte · Tapentadol retard CF 250 mg, tabletten met verlengde afgifte · Tapentadol retard CF 50 mg, tabletten met verlengde afgifte · Tapentadol retard Teva 100 mg, tabletten met verlengde afgifte · Tapentadol retard Teva 150 mg, tabletten met verlengde afgifte · Tapentadol retard Teva 200 mg, tabletten met verlengde afgifte · Tapentadol retard Teva 25 mg, tabletten met verlengde afgifte · Tapentadol retard Teva 250 mg, tabletten met verlengde afgifte · Tapentadol retard Teva 50 mg, tabletten met verlengde afgifte · Tapentadol Retard Viatris 100 mg, tabletten met verlengde afgifte · Tapentadol Retard Viatris 150 mg, tabletten met verlengde afgifte · Tapentadol Retard Viatris 200 mg, tabletten met verlengde afgifte · Tapentadol Retard Viatris 25 mg, tabletten met verlengde afgifte · Tapentadol Retard Viatris 250 mg, tabletten met verlengde afgifte · Tapentadol Retard Viatris 50 mg, tabletten met verlengde afgifte · Tapentadol Retard Xiromed 100 mg tabletten met verlengde afgifte · Tapentadol Retard Xiromed 150 mg tabletten met verlengde afgifte · Tapentadol Retard Xiromed 200 mg tabletten met verlengde afgifte · Tapentadol Retard Xiromed 25 mg tabletten met verlengde afgifte · Tapentadol Retard Xiromed 250 mg tabletten met verlengde afgifte · Tapentadol Retard Xiromed 50 mg tabletten met verlengde afgifte 
Palexia 100 mg compr. pellic. · Palexia 20 mg/ml sol. buv. · Palexia 4 mg/ml sol. buv. · Palexia 50 mg compr. pellic. · Palexia 75 mg compr. pellic. · Palexia Retard 100 mg compr. lib. prol. · Palexia Retard 150 mg compr. lib. prol. · Palexia Retard 200 mg compr. lib. prol. · Palexia Retard 25 mg compr. lib. prol. · Palexia Retard 250 mg compr. lib. prol. · Palexia Retard 50 mg compr. lib. prol. · Tapentadol Retard Laboratorios Liconsa 100 mg compr. lib. prol. · Tapentadol Retard Laboratorios Liconsa 150 mg compr. lib. prol. · Tapentadol Retard Laboratorios Liconsa 200 mg compr. lib. prol. · Tapentadol Retard Laboratorios Liconsa 25 mg compr. lib. prol. · Tapentadol Retard Laboratorios Liconsa 250 mg compr. lib. prol. · Tapentadol Retard Laboratorios Liconsa 50 mg compr. lib. prol. 
Pagrentil · Pagrentil Retard 100 mg Comprimidos de Liberaci?n Prolongada efg · Pagrentil Retard 150 mg Comprimidos de Liberaci?n Prolongada efg · Pagrentil Retard 200 mg Comprimidos de Liberaci?n Prolongada efg · Pagrentil Retard 250 mg Comprimidos de Liberaci?n Prolongada efg · Pagrentil Retard 50 mg Comprimidos de Liberaci?n Prolongada efg · PALEXIA 100 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Palexia 20 mg/ml Solucion Oral · Palexia 4 mg/ml Solucion Oral · PALEXIA 50 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · PALEXIA 75 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · PALEXIA RETARD 100 mg COMPRIMIDOS DE LIBERACION PROLONGADA · PALEXIA RETARD 150 mg COMPRIMIDOS DE LIBERACION PROLONGADA · PALEXIA RETARD 200 mg COMPRIMIDOS DE LIBERACION PROLONGADA · PALEXIA RETARD 25 mg COMPRIMIDOS DE LIBERACION PROLONGADA · PALEXIA RETARD 250 mg COMPRIMIDOS DE LIBERACION PROLONGADA · PALEXIA RETARD 50 mg COMPRIMIDOS DE LIBERACION PROLONGADA · Palgesic · Palgesic Retard 100 mg Comprimidos de Liberaci?n Prolongada efg · Palgesic Retard 150 mg Comprimidos de Liberaci?n Prolongada efg · Palgesic Retard 200 mg Comprimidos de Liberaci?n Prolongada efg · Palgesic Retard 25 mg Comprimidos de Liberaci?n Prolongada efg · Palgesic Retard 250 mg Comprimidos de Liberaci?n Prolongada efg · Palgesic Retard 50 mg Comprimidos de Liberaci?n Prolongada efg · Remuva · Remuva 100 mg Comprimidos de Liberaci?n Prolongada efg · Remuva 200 mg Comprimidos de Liberaci?n Prolongada efg · Remuva 250 mg Comprimidos de Liberaci?n Prolongada efg · Remuva 50 mg Comprimidos de Liberaci?n Prolongada efg · Tapentadol · Tapentadol Krka 100 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Krka 150 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Krka 50 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Retard Stada 100 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Retard Stada 150 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Retard Stada 200 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Retard Stada 25 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Retard Stada 250 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Retard Stada 50 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Retard Zentiva 100 mg Comprimidos de Liberaci?n Prolongada efg · Tapentadol Retard Zentiva 150 mg Comprimidos de Liberaci?n Prolongada efg · Tapentadol Retard Zentiva 25 mg Comprimidos de Liberaci?n Prolongada efg · Tapentadol Retard Zentiva 250 mg Comprimidos de Liberaci?n Prolongada efg · Tapentadol Retard Zentiva 50 mg Comprimidos de Liberaci?n Prolongada efg · Tapentadol Teva 100 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Teva 25 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Teva 250 mg Comprimidos de Liberacion Prolongada efg · Tapentadol Teva 50 mg Comprimidos de Liberacion Prolongada efg · Tapimio · Tapimio 200 mg Comprimidos de Liberaci?n Prolongada efg · Tapimio 50 mg Comprimidos de Liberaci?n Prolongada efg · Yantil · YANTIL 100 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Yantil 20 mg/ml Solucion Oral · Yantil 4 mg/ml Solucion Oral · YANTIL 50 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · YANTIL 75 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · YANTIL RETARD 100 mg COMPRIMIDOS DE LIBERACION PROLONGADA · YANTIL RETARD 150 mg COMPRIMIDOS DE LIBERACION PROLONGADA · Yantil Retard 25 mg Comprimidos de Liberacion Prolongada · YANTIL RETARD 250 mg COMPRIMIDOS DE LIBERACION PROLONGADA 
Palexia · Tadomon · Tapelod 
DOLTEN 100 mg · DOLTEN 50 mg · DOLTEN 75 mg 
Ationdo · Lupaxis · Palexia · Palexia SR · Tadomon · Tapentadol · Tapimio · Vecicom 
Palexia · Palexia Depot · Tapentadol Aristo · Tapentadol Carefarm · Tapentadol G.L. Pharma · Tapentadol Krka · Tapentadol Medical Valley · Tapentadol Stada · Tapentadol Teva · Tapentadol Zentiva 
Palexia · Palexia depot · Tapentadol Medical Valley 
Adoben · Binatta · Palexia · Palexia retard · Tadomon 
Palexia · Palexia Retard · Tapentadol G.L. 
Tapentadol STADA 
Apeneta® · Palexia® · Palexia®SR
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