Monograph
A10BD08 - Metformin and Vildagliptin |
Propably not porphyrinogenic |
PNP |
Rationale
Neither metformin nor vildagliptin have the potential to inhibit or induce CYP enzymes. No porphyrinogenic physiological effects. Vomiting and loss of appetite is potentially porphyrogenic side effects through interference with nutrition and motivates attendance.
Chemical description
Metformin is a biguanide anti-diabetic. Vildagliptine is a hydroxyadmantane pyrrolidine carbonitrile anti-diabetic.
Therapeutic characteristics
Metformin and vildagliptin are indicated for the improvement of glycaemic control in adult patients with type 2 diabetes mellitus. Vomiting and loss of appetite are potentially porphyrogenic side effects through interference with nutrition intake.
Metabolism and pharmacokinetics
Neither metformin nor vildagliptin are metabolized via CYP enzymes.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors.
Golightly LK, Drayna CC, et al. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14. |
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| 2. | Clinical pharmacokinetics and pharmacodynamics of vildagliptin.
He YL. Clin Pharmacokinet. 2012 Mar 1;51(3):147-62. |
22339447 |
| 3. | Pharmacokinetics of dipeptidylpeptidase-4 inhibitors.
Scheen AJ. Diabetes Obes Metab. 2010 Aug; 12(8):648-58. |
20590741 |
| 4. | Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications.
Tornio A, Niemi M, et al. Trends Pharmacol Sci. 2012 Jun;33(6):312-22. |
22475684 |
| * | Summary of Product Characteristics | |
| 5. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Eucreas.
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| * | Other sources | |
| 6. | See also the monographs of metformin (ATC A10BA02) and of vildagliptin (ATC A10BH02).
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Eucreas 50 mg/1000 mg, filmomhulde tablet · Eucreas 50 mg/850 mg, filmomhulde tablet · Icandra 50 mg / 1000 mg, filmomhulde tabletten · Icandra 50 mg / 850 mg, filmomhulde tabletten · Metformin / Vildagliptin · Zomarist 50 mg/ 1000 mg, filmomhulde tablet · Zomarist 50 mg/850 mg, filmomhulde tablet 
Eucreas 50 mg - 1 000 mg compr. pellic. · Eucreas 50 mg - 850 mg compr. pellic. · Icandra 50 mg - 1 000 mg compr. pellic. · Icandra 50 mg - 850 mg compr. pellic. · Metformin / Vildagliptin · Zomarist 50 mg - 1 000 mg compr. pellic. · Zomarist 50 mg - 850 mg compr. pellic. 
Daltex 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Daltex 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · EUCREAS 50 mg/1000 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · EUCREAS 50 mg/850 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · ICANDRA 50 mg/1000 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · ICANDRA 50 mg/850 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Ipinzan 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Ipinzan 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Almus 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Alter 50 mg/1.000 mg Comprimidos efg · Vildagliptina/Metformina Alter 50 mg/850 mg Comprimidos efg · Vildagliptina/Metformina Aurovitas 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Cinfa 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Cinfa 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Combix 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Combix 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Intas 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Intas 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Kern Pharma 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Kern Pharma 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Krka 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Krka 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Macleods 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Macleods 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Normon 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Normon 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Pensa 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Pensa 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Ratiopharm 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Ratiopharm 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Sandoz 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Sandoz 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Stada 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Stada 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Swanpond Investments 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Tecnigen 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Tecnigen 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Teva 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Teva 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina Viatris 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina vir 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vildagliptina/Metformina vir 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vilspox 50 mg/1000 mg Comprimidos Recubiertos con Pelicula efg · Vilspox 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Vimetso 50 mg/1.000 mg Comprimidos Recubiertos con Pelicula efg · Vimetso 50 mg/850 mg Comprimidos Recubiertos con Pelicula efg · Zomarist 50 mg/1000 mg Comprimidos Recubiertos con Pelicula · Zomarist 50 mg/850 mg Comprimidos Recubiertos con Pelicula 
Eucreas · Metformin / Vildagliptin 
AGARTHA DUO 50 mg/1000 mg · AGARTHA DUO 50 mg/850 mg · DALTEX 50 mg/1000 mg · DALTEX 50 mg/850 mg · EUCREAS 50mg/1000mg · EUCREAS 50mg/850mg · GLUAMET 50 mg/1000 mg · GLUAMET 50 mg/850 mg · IPINZAN 50 mg/1000 mg · IPINZAN 50 mg/850 mg · MELKART DUO 50 mg/1000 mg · MELKART DUO 50 mg/850 mg 
Eucreas · Metformin / Vildagliptin 
Daltex · Diptivil Duo · Eucreas · Icandra · Ipinzan · Metformin / Vildagliptin · Tutecvi Combi · Vedfa · Veldamet · Vilmenio · Zomarist 
Eucreas · Metformin / Vildagliptin 
Agartha DUO · Alikval Duo · Anvildis Duo · Eucreas · Gliptivil Combo · GluaMet · Icandra · Ipinzan · Melkart Duo · Metformin / Vildagliptin · Pernuvi Combi · Vimetso · Zomarist 
Eucreas 50/1000 · Eucreas 50/850 
Eucreas · Icandra · Metformin / Vildagliptin · Zomarist 
Eucreas · Icandra · Metformin / Vildagliptin · Zomarist 
Daltex · Eucreas · Icandra · Ipinzan · Metformin / Vildagliptin · Vilspox · Vimetso · Zomarist 
Agnis® Plus · Criteo® duo
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