Monograph

A10AE06 - Insulin Degludec

Not porphyrinogenic

Rationale

Insulin degludec has no porphyrinogenic effects.

Chemical description

Antidiabetic pancreatic hormone consisting of polypeptide chains, connected by disulfide bridges.

Metabolism and pharmacokinetics

Insulin degludec is a basal insulin that forms soluble multi-hexamers upon subcutaneous injection, which are slowly and continuously absorbed into the bloodstream leading to a flat and stable glucose-lowering-effect. Degradation of insulin degludec is similar to that of human insulin; all metabolites formed are inactive.

Similar drugs

Explore alternative drugs in similar therapeutic classes A10A / A10AE or go back.

References

#	Citation details	PMID
*	Scientific articles
1.	Degludec, a new ultra-long-acting basal insulin for the treatment of diabetes mellitus type 1 and 2: advances in clinical research. Muñoz Torres M. Endocrinol Nutr. 2014 Mar;61(3):153-9.	23890782
*	Summary of Product Characteristics
2.	The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Tresiba.

Citation details

PMID

Scientific articles

Degludec, a new ultra-long-acting basal insulin for the treatment of diabetes mellitus type 1 and 2: advances in clinical research.

Muñoz Torres M. Endocrinol Nutr. 2014 Mar;61(3):153-9.

23890782

Summary of Product Characteristics

The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Tresiba.

Tradenames

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