Monograph

A16AA05 - Carglumic Acid

Not porphyrinogenic

Rationale

Non-Cyp metabolism of carbamoylated aminoacid. No conceivable physiological effects or side effects. Several indications relate to newborn or prepubertal children.

Chemical description

Carbamoyl glutamic acid. Structural analogue to N-acetyl glutamic acid, the physiological activator of hepatic carbamoylfosfate syntetase.

Therapeutic characteristics

Activator of hepatic acetylglutamate syntetase, the initial enzyme in urea biosynthesis. Under conditions of hyperammonemia the levels of ammoniac decreases and those of urea increases.

Hepatic exposure

Significant.

Metabolism and pharmacokinetics

About 30 % of the dose is absorbed giving a plasma concentration of 2-5 ug/ml. Partly metabolized to glutamic acid, and to carbon dioxide eliminated by the lungs.

Similar drugs

Explore alternative drugs in similar therapeutic classes A16A / A16AA or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Carbaglu · Carbaglu 200 mg, dispergeerbare tabletten · Carglumaatzuur · Carglumaatzuur Tillomed 200 mg dispergeerbare tabletten · Carglumaatzuur Waymade 200 mg dispergeerbare tabletten · Ucedane · Ucedane 200 mg dispergeerbare tabletten

Belgium

Carbaglu · Carbaglu 200 mg compr. disp. · Ucedane · Ucedane 200 mg compr. disp.

United Kingdom

Carbaglu · Carbaglu 200mg dispersible tablets · Carglumic acid · Carglumic acid 200mg dispersible tablets sugar free · Ucedane · Ucedane 200mg dispersible tablets

Denmark