Monograph

A16AA05 - Carglumic Acid

Not porphyrinogenic

Rationale

Non-Cyp metabolism of carbamoylated aminoacid. No conceivable physiological effects or side effects. Several indications relate to newborn or prepubertal children.

Chemical description

Carbamoyl glutamic acid. Structural analogue to N-acetyl glutamic acid, the physiological activator of hepatic carbamoylfosfate syntetase.

Therapeutic characteristics

Activator of hepatic acetylglutamate syntetase, the initial enzyme in urea biosynthesis. Under conditions of hyperammonemia the levels of ammoniac decreases and those of urea increases.

Hepatic exposure

Significant.

Metabolism and pharmacokinetics

About 30 % of the dose is absorbed giving a plasma concentration of 2-5 ug/ml. Partly metabolized to glutamic acid, and to carbon dioxide eliminated by the lungs.

Similar drugs

Explore alternative drugs in similar therapeutic classes A16A / A16AA or go back.

Tradenames

This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.

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Show more details and information about the listed tradenames

Carbaglu 200 mg, dispergeerbare tabletten · Carglumaatzuur Tillomed 200 mg dispergeerbare tabletten · Carglumaatzuur Waymade 200 mg dispergeerbare tabletten · Ucedane 200 mg dispergeerbare tabletten

Carbaglu 200 mg compr. disp. · Ucedane 200 mg compr. disp.

Acido Carglumico Tillomed 200 mg Comprimidos Dispersables efg · Acido Carglumico Waymade 200 mg Comprimidos Dispersables efg · CARBAGLU 200 mg COMPRIMIDOS DISPERSABLES · Ucedane 200 mg Comprimidos Dispersables efg