A02BA01 - Cimetidine |
Not porphyrinogenic |
NP |
Rationale
Only metabolised to a minor extent. Unspecific CYP-inhibitor (CYPs 2C9, 11B1, 1A2, 2C19, 2D6, 2E1, 3A4). To be observed: Imidazole is an CYP2E1 inducer. Several references consider it safe or probably safe. Also repeatedly used without porphyrogenic side effects.
Chemical description
Imidazole histamine-receptor antagonist used in ventricular hyperacidity. Slightly (10-15%) metabolized enzymatically to sulfdioxide. In large parts excreted unchanged in urine. Unspecific CYP-inhibitor which has been used in the treatment of the acute porphyric attack.
Personal communication
Andersson D: Frequently used without porphyric side effects.
Andersson C: Patient reports, tolerated (n=2).
IPNet drug reports
Uneventful use reported in 3 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | French List
Centre Français des Porphyries
|
|
| 2. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Cimetidine 
Cimetidine 
Cimetidina 
Acid-Eze · Acitak · Cimetidine · Dyspamet · Galenamet · Peptimax 200 · Peptimax 400 · Tagadine · Tagamet · Tagamet 100 · Ultec · Zita 
Acinil · Cimetidin · Cimetidine · Tagamet · Ulcostad 
Cimetidin · Cimetidine · Ulcostad 
Cimetidine · Contracid · Cytine · Duomet · Primamet 
Cimetidine · Shintamet · Xepamet 
Cimetidine 
h2-Blocker 
Altramet · Belomet · Cimetidin