Monograph
A02BA03 - Famotidine |
Propably not porphyrinogenic |
PNP |
Rationale
Partly unmetabolized. No clinical observations pointing to CYP inducing properties.
Chemical description
Used in peptic ulcer and gastro-oesophageal reflux (H2-receptor antagonist). About 70% excreted in urine in unmetabolized form. Partly metabolized in the liver to inactive sulfoxide metabolite. Impaired liver function does not seem to change the kinetics. South African list: use with care. French list: avoid Australian list: safe
IPNet drug reports
Uneventful use reported in 8 patients with acute porphyria.
Similar drugs
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