Monograph

C01CA06 - Phenylephrine

Propably not porphyrinogenic

Rationale

/Most recent revision Febr 14 2004 (Pomp). / Hydrophilic substance similar to endogenous adrenaline. Non-CYP metabolism. No data pointing to CYP/NR interaction.

Chemical description

Adrenergic, used parenterally in regional anaesthesia, in severe hypotension and in paroxysmal tachycardia. Nasal and ophtalmic preparations are in use on other indications. Hydrophilic substance with chemical structure similiar to endogenous adrenaline, but lacks one hydroxy-group in the aromatic ring. Oxidative deamination is the predominant metabolic pahway, probably as for endogenous monoamines. Hepatic exposure may exceed the uM range in treatment of severe hypotension, but probably not when used in regional anaesthesia. Elimination half life of the parent compound 2-3 hours. No data pointing to CYP metabolism or other CYP/NR interactions. J Goto et al. Autonomic dysfunction in acute intermittent porphyria. Rinsho Shinkeigaku 1989; 29:774-7. (PMID 2582692).

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Tradenames

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Biorphen 0,1 mg/ml, oplossing voor injectie/infusie · Biorphen 10 mg/ml, oplossing voor injectie · Fenylefrine Added Pharma 100 microgram/ml, oplossing voor injectie · Fenylefrine Added Pharma 50 microgram/ml, oplossing voor injectie · Fenylefrine Aguettant 100 microgram/ml oplossing voor injectie of infusie · Fenylefrine Aguettant 50 microgram/ml, oplossing voor injectie in voorgevulde spuit · Fenylefrine Altan 0,08 mg/ml oplossing voor injectie/infusie · Fenylefrine Unimedic 0,1 mg/ml, oplossing voor injectie · Fenylefrine Unimedic 10 mg/ml, concentraat voor oplossing voor injectie/infusie

Phenylephrine · Phenylephrine Aguettant 100 ?g/ml sol. inj./perf. i.v. flac. · Phenylephrine Aguettant 50 ?g/ml sol. inj. i.v. ser. pr?remplie · Phenylephrine Unimedic 10 mg/ml sol. inj./perf. (sol., ? diluer) i.v. amp.

Fenilefrina · Fenilefrina Aguettant 100 Microgramos/ml Solucion Inyectable y Para Perfusion · Fenilefrina Altan 0,1 mg/ml Solucion Inyectable y Para Perfusion · HIDROCLORURO DE FENILEFRINA ALTAN 10 mg/ml SOLUCION INYECTABLE