Monograph

C01CA06 - Phenylephrine

Propably not porphyrinogenic

Rationale

/Most recent revision Febr 14 2004 (Pomp). / Hydrophilic substance similar to endogenous adrenaline. Non-CYP metabolism. No data pointing to CYP/NR interaction.

Chemical description

Adrenergic, used parenterally in regional anaesthesia, in severe hypotension and in paroxysmal tachycardia. Nasal and ophtalmic preparations are in use on other indications. Hydrophilic substance with chemical structure similiar to endogenous adrenaline, but lacks one hydroxy-group in the aromatic ring. Oxidative deamination is the predominant metabolic pahway, probably as for endogenous monoamines. Hepatic exposure may exceed the uM range in treatment of severe hypotension, but probably not when used in regional anaesthesia. Elimination half life of the parent compound 2-3 hours. No data pointing to CYP metabolism or other CYP/NR interactions. J Goto et al. Autonomic dysfunction in acute intermittent porphyria. Rinsho Shinkeigaku 1989; 29:774-7. (PMID 2582692).

Similar drugs

Explore alternative drugs in similar therapeutic classes C01C / C01CA or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Biorphen · Biorphen 0,1 mg/ml, oplossing voor injectie/infusie · Biorphen 10 mg/ml, oplossing voor injectie · Fenylefrine · Fenylefrine Added Pharma 100 microgram/ml, oplossing voor injectie · Fenylefrine Added Pharma 50 microgram/ml, oplossing voor injectie · Fenylefrine Aguettant 100 microgram/ml oplossing voor injectie of infusie · Fenylefrine Aguettant 50 microgram/ml, oplossing voor injectie in voorgevulde spuit · Fenylefrine Altan 0,08 mg/ml oplossing voor injectie/infusie · Fenylefrine Unimedic 0,1 mg/ml, oplossing voor injectie · Fenylefrine Unimedic 10 mg/ml, concentraat voor oplossing voor injectie/infusie

Belgium

Phenylephrine · Phenylephrine Aguettant 100 µg/ml sol. inj./perf. i.v. flac. · Phenylephrine Aguettant 50 µg/ml sol. inj. i.v. ser. préremplie · Phenylephrine Unimedic 10 mg/ml sol. inj./perf. (sol., à diluer) i.v. amp.

United Kingdom

Phenylephrine · Phenylephrine 10mg/1ml concentrate for solution for injection ampoules · Phenylephrine 10mg/1ml solution for injection ampoules · Phenylephrine 125micrograms/10ml solution for injection ampoules · Phenylephrine 125micrograms/10ml solution for injection vials · Phenylephrine 1mg/10ml solution for injection ampoules · Phenylephrine 1mg/10ml solution for injection pre-filled syringes · Phenylephrine 1mg/20ml solution for injection ampoules · Phenylephrine 200micrograms/1ml solution for injection ampoules · Phenylephrine 2mg/20ml solution for injection ampoules · Phenylephrine 2mg/20ml solution for injection vials · Phenylephrine 3mg/30ml solution for injection pre-filled syringes · Phenylephrine 500micrograms/10ml solution for injection ampoules · Phenylephrine 500micrograms/10ml solution for injection pre-filled syringes · Phenylephrine 50mg/5ml solution for injection ampoules · Phenylephrine 7.5mg/0.5ml solution for injection ampoules · Phenylephrine 8mg/100ml infusion bags

Denmark