Monograph

C01CA07 - Dobutamine

Not porphyrinogenic

Rationale

Non-CYP metabolism. No data pointing to CYP-interaction. Four lists stating non-porphyrinogenicity.

Chemical description

Therapeutic characteristics

Synthetic catecholamine used in acute heart failure due to its inotropic effects on the heart. Given in infusion 0.25-1 g/l.

Metabolism and pharmacokinetics

Metabolized in tissues and in the liver. Conjugated to glucuronic acid and methylated by COMT. Excreted in urine within six hours as glucuronide conjugates.

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C01C / C01CA or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Dobutamine · Dobutamine CF 12,5 mg/ml, concentraat voor oplossing voor intraveneuze infusie · Dobutamine SUN 5 mg/ml oplossing voor infusie in voorgevulde spuit · Dobutamine-hameln 12,5 mg/ml steriel concentraat, concentraat voor oplossing voor infusie · Dobutamine-hameln 5 mg/ml i.v. infusievloeistof, oplossing voor infusie

Belgium

Dobutrexviatris · Dobutrexviatris 250 mg/20 ml sol. perf. (à diluer) i.v. flac.

United Kingdom

Dobutamine · Dobutamine 100mg/100ml infusion bags · Dobutamine 250mg/20ml concentrate for solution for infusion ampoules · Dobutamine 250mg/50ml solution for infusion pre-filled syringes · Dobutamine 250mg/50ml solution for infusion vials · Dobutamine 500mg/100ml infusion bags · Dobutamine 60mg/50ml solution for infusion pre-filled syringes · Dobutrex · Dobutrex 250mg/20ml solution for infusion vials · Posiject · Posiject 250mg/5ml solution for infusion ampoules

Denmark