Monograph

A03AA04 - Mebeverine

Propably not porphyrinogenic

Rationale

Mebeverine is not listed as a CYP-inducer or inhibitor, and is not known to interfere with the CYP-metabolism of other drugs. There are no indications of porphyrinogenic effects connected with the pharmacodynamic properties of the drug. Some preparations may include the laxative ispanhula, which also is classified PNP.

Chemical description

Mebeverine is the veratric acid ester of a substituted ethylamphetamine derivative.

Therapeutic characteristics

Mebeverine is an antispasmodic used in conditions such as irritable bowel syndrome. It is administered orally.

Metabolism and pharmacokinetics

Mebeverine is metabolised by hydrolysis to veratric acid and mebeverine alcohol. Mebeverine alcohol may go through further breakdown and conjugation before it is renally excreted.

Preclinical data

Moore and Hift claims porphyrinogenisity is shown in in vitro studies, but gives no references.

IPNet drug reports

Uneventful use reported in 2 patients with acute porphyria.

References

#	Citation details	PMID
*	Scientific articles
1.	Investigative implications of the instability and metabolism of mebeverine. Elliott S, Burgess V. J Anal Toxicol. 2006 Mar;30(2):91-7.	16620538
2.	Drugs in the acute porphyrias - toxicogenetic diseases. Cell Mol Biol (Noisy-le-grand). 1997 Feb;43(1):89-94. Moore MR, Hift RJ.	9074793
*	Drug reference publications
3.	Sweetman SC, editor. Martindale: The complete drug reference. Mebeverine. Pharmaceutical Press 2009.
*	Summary of Product Characteristics
4.	The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Colofac MR.

Citation details

PMID

Scientific articles

Investigative implications of the instability and metabolism of mebeverine.

Elliott S, Burgess V. J Anal Toxicol. 2006 Mar;30(2):91-7.

16620538

Drugs in the acute porphyrias - toxicogenetic diseases. Cell Mol Biol (Noisy-le-grand). 1997 Feb;43(1):89-94.

Moore MR, Hift RJ.

9074793

Drug reference publications

Sweetman SC, editor. Martindale: The complete drug reference. Mebeverine. Pharmaceutical Press 2009.

Summary of Product Characteristics

The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Colofac MR.

Similar drugs

Explore alternative drugs in similar therapeutic classes A03A / A03AA or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Duspatal · Duspatal 135 mg, omhulde tabletten · Duspatal Retard 200 mg, capsules met gereguleerde afgifte · Duspatal Retard 200 mg, harde capsules met gereguleerde afgifte · Mebeverine · Mebeverine HCl Aristo 200 mg harde capsules met gereguleerde afgifte · Mebeverine HCl Aurobindo Retard 200 mg, harde capsules met gereguleerde afgifte · Mebeverine HCl retard 200 mg, capsules met gereguleerde afgifte

Belgium

Duspatalin · Duspatalin 135 mg compr. enr. · Duspatalin Retard 200 mg (PI Pharma) gél. lib. prol. · Duspatalin Retard 200 mg gél. lib. prol. · Mebeverine · Mebeverine AB 200 mg gél. lib. modif. · Mebeverine EG 135 mg compr. pellic.

United Kingdom

Aurobeverine · Aurobeverine MR 200mg capsules · Boots IBS Relief · Boots IBS Relief 135mg tablets · Colofac · Colofac 135mg tablets · Colofac 50mg/5ml liquid · Colofac 100 · Colofac 100 tablets · Colofac IBS · Colofac IBS 135mg tablets · Colofac MR · Colofac MR 200mg capsules · Equilon · Equilon 135mg tablets · Mebeverine · Mebeverine 135mg oral powder sachets · Mebeverine 135mg tablets · Mebeverine 150mg/5ml oral suspension · Mebeverine 200mg modified-release capsules · Mebeverine 50mg/5ml oral suspension · Mebeverine 50mg/5ml oral suspension sugar free

Denmark