N05BA04 - Oxazepam |
Probably not porphyrinogenic |
PNP |
Rationale
Directly conjugated with glucuronic acid. References consider it safe
Chemical description
Benzodiazepine with anxiolytic, sedative and muscle relaxing properties. Rapidly and directly glucuronidated due to an active OH-group (not present in diazepam, clopoxide or nitrazepam). Does not form any active metabolites and is eliminated by the kidneys with a half time of 10 hours. Conflicting experimental evidence of porphyrinogenicity (Martindale).
Personal communication
Thunell, patient inquiry: Tolerated (n=1).
IPNet drug reports
Uneventful use reported in 20 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Drug reference publications | ||
| 1. | Martindale: The complete drug reference. Pharmaceutical Press.
Sweetman SC, editor.
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| Porphyria Drug Lists | ||
| 2. | Australian List
Australian Porphyria Association No longer maintained
|
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| 3. | French List
Centre Français des Porphyries
|
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| 4. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 5. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Oxazepam 
Oxazepam 
Seresta 
Serpax 
Anxiolit · Seresta · Seresta forte 
Oxazepam 
Oxabenz · Oxapax · Oxazepam 
Delipam · Oxascand · Sobril 
Delipam · Sobril 
Oksazepam · Oxazepam 
Adumbran · Benzotran · Ox-Pam · Serepax 
Oxazepam 
Oxazepam 
Sobril 
Opamox · Oxamin 
Nozepam · Tazepam 
Nozepam · Tazepam 
Oxazepam 
Oksazepam 
Oksazepam · Praxiten 
Adumbran · Oksazepam · Praxiten 
Oxazepam 
Lederpam · Oxazepam · Serax · Serenid · Zaxopam 
Oxazepam