N05BA04 - Oxazepam |
Probably not porphyrinogenic |
PNP |
Rationale
Directly conjugated with glucuronic acid. References consider it safe
Chemical description
Benzodiazepine with anxiolytic, sedative and muscle relaxing properties. Rapidly and directly glucuronidated due to an active OH-group (not present in diazepam, clopoxide or nitrazepam). Does not form any active metabolites and is eliminated by the kidneys with a half time of 10 hours. Conflicting experimental evidence of porphyrinogenicity (Martindale).
Personal communication
Thunell, patient inquiry: Tolerated (n=1).
IPNet drug reports
Uneventful use reported in 20 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Drug reference publications | ||
| 1. | Martindale: The complete drug reference. Pharmaceutical Press.
Sweetman SC, editor.
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| Porphyria Drug Lists | ||
| 2. | Australian List
Australian Porphyria Association No longer maintained
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| 3. | French List
Centre Français des Porphyries
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| 4. | EPI List
European Porphyria Initiative No longer maintained
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| 5. | South African List
Porphyria South Africa No longer maintained
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Tradenames