Monograph
R03AK06 - Salmeterol and Fluticasone |
Propably not porphyrinogenic |
PNP |
Rationale
salmeterol: Substrate for CYP 3A4. Probably insignificant metabolic load. Fluticasone: Probably insignificant systemic exposure. Several references stating non-porphyrinogenic metabolism of glucocorticoids.
Chemical description
salmeterol Adrenergic administered in asthma in inhalation aerosol, 50 µg/dose. Gives rise only to very low plasma concentrations. Metabolized in the liver (CYP 3A4) producing several metabolites. fluticasone Antiasthmatic antiinflammatory glucocorticoide, administered as inhalation powder (50 - 250 µg/dose). Systemic exposure about 16% of the taken dose. Rapidly metabolized by CYP 3A4 (within 3-4 hours). glucocorticoides: EPI-list: safe French list: authorized South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: safe Moore MR, Hift RJ: safe French list: authorized South African list: use
IPNet drug reports
Uneventful use reported in 7 patients with acute porphyria.
Similar drugs
Tradenames
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AirFluSal · AirFluSal A?rosol 25/125 microgram, a?rosol, suspensie · AirFluSal A?rosol 25/250 microgram, a?rosol, suspensie · AirFluSal Forspiro 50/500 microgram/dosis, inhalatiepoeder, voorverdeeld · BroPair · BroPair? Spiromax?, 14 microgram/113 microgram, inhalatie poeder · BroPair? Spiromax?, 14 microgram/232 microgram, inhalatie poeder · Salflutin 50 microgram/500 microgram/dosis inhalatiepoeder, voorverdeeld · Salfuler Easyhaler 50/500 microgram/dosis, inhalatiepoeder · Salmeterol / Fluticasonpropionaat · Salmeterol/Fluticasonpropionaat 25 microgram/125 microgram/dosis Vincion, a?rosol, suspensie · Salmeterol/Fluticasonpropionaat 25 microgram/250 microgram/dosis Vincion, a?rosol, suspensie · Salmeterol/Fluticasonpropionaat Allgen 25 microgram/125 microgram/dosis a?rosol, suspensie · Salmeterol/Fluticasonpropionaat Allgen 25 microgram/250 microgram/dosis a?rosol, suspensie · Salmeterol/Fluticasonpropionaat Allgen 25 microgram/50 microgram/dosis a?rosol, suspensie · Salmeterol/Fluticasonpropionaat Elpen 50 microgram/250 microgram/dosis inhalatiepoeder, voorverdeeld · Salmeterol/Fluticasonpropionaat Elpen 50 microgram/500 microgram/ dosis inhalatiepoeder, voorverdeeld · Salmeterol/Fluticasonpropionaat Genetic 50 microgram/100 microgram/dosis voorverdeeld inhalatiepoeder · Salmeterol/Fluticasonpropionaat Genetic 50 microgram/250 microgram/dosis voorverdeeld inhalatiepoeder · Salmeterol/Fluticasonpropionaat Genetic 50 microgram/500 microgram/dosis voorverdeeld inhalatiepoeder · Salmeterol/Fluticasonpropionaat Glenmark 25 microgram/125 microgram/dosis a?rosol, suspensie · Salmeterol/Fluticasonpropionaat Glenmark 25 microgram/250 microgram/dosis a?rosol, suspensie · Salmeterol/Fluticasonpropionaat Glenmark 25 microgram/50 microgram/dosis a?rosol, suspensie · Salmeterol/Fluticasonpropionaat Neutec 50 microgram/100 microgram inhalatiepoeder, voorverdeeld · Salmeterol/Fluticasonpropionaat Neutec 50 microgram/250 microgram inhalatiepoeder, voorverdeeld · Salmeterol/Fluticasonpropionaat Neutec 50 microgram/500 microgram voorverdeeld inhalatiepoeder · Salmeterol/Fluticasonpropionaat Sandoz 25/125 microgram, aerosol, suspensie · Salmeterol/Fluticasonpropionaat Sandoz 25/250 microgram, aerosol, suspensie · Seffalair · Seffalair Spiromax 14/113 ?g, inhalatiepoeder · Seffalair Spiromax 14/232 ?g, inhalatiepoeder · Serair 50 microgram/100 microgram inhalatiepoeder, voorverdeeld · Serair 50 microgram/250 microgram inhalatiepoeder, voorverdeeld · Serair 50 microgram/500 microgram inhalatiepoeder, voorverdeeld · Sereflo Ciphaler 50 microgram / 250 microgram per dosis, inhalatiepoeder, voorverdeeld · Sereflo Ciphaler 50 microgram / 500 microgram per dosis, voorverdeeld inhalatiepoeder · Seretide 
Aerivio · Aerivio Spiromax 50 ?g - 500 ?g pdr. inhal. inhalateur · Airflusal · Airflusal Forspiro 50 ?g/dose - 250 ?g/dose pdr. inhal. (r?cip. unidose) · Airflusal Forspiro 50 ?g/dose - 500 ?g/dose pdr. inhal. (r?cip. unidose) · Aurocombo · Aurocombo 50 ?g/dose - 100 ?g/dose pdr. inhal. (r?cip. unidose) · Aurocombo 50 ?g/dose - 250 ?g/dose pdr. inhal. (r?cip. unidose) · Aurocombo 50 ?g/dose - 500 ?g/dose pdr. inhal. (r?cip. unidose) · Brecur · Brecur Airmaster 50 ?g/dose - 100 ?g/dose pdr. inhal. (r?cip. unidose) · Brecur Airmaster 50 ?g/dose - 250 ?g/dose pdr. inhal. (r?cip. unidose) · Brecur Airmaster 50 ?g/dose - 500 ?g/dose pdr. inhal. (r?cip. unidose) · BroPair · BroPair Spiromax 12.75 ?g - 100 ?g pdr. inhal. r?cip. multidos. · BroPair Spiromax 12.75 ?g - 202 ?g pdr. inhal. r?cip. multidos. · Flutisacombo · Flutisacombo 25 ?g/dose - 125 ?g/dose susp. inhal. (flacon press.) r?cip. pressur. · Flutisacombo 25 ?g/dose - 250 ?g/dose susp. inhal. (flacon press.) r?cip. pressur. · Flutisacombo 25 ?g/dose - 50 ?g/dose susp. inhal. (flacon press.) r?cip. pressur. · Flutisamix · Flutisamix Easyhaler 50 ?g/dose - 250 ?g/dose pdr. inhal. inhalateur · Flutisamix Easyhaler 50 ?g/dose - 500 ?g/dose pdr. inhal. inhalateur · Salmeterol / Fluticasone · Salmeterol/Fluticasone Genetic 50 ?g/dose - 100 ?g/dose pdr. inhal. (r?cip. unidose) · Salmeterol/Fluticasone Genetic 50 ?g/dose - 250 ?g/dose pdr. inhal. (r?cip. unidose) · Salmeterol/Fluticasone Genetic 50 ?g/dose - 500 ?g/dose pdr. inhal. (r?cip. unidose) · Seffalair · Seffalair Spiromax 12.75 ?g - 100 ?g pdr. inhal. r?cip. multidos. · Seffalair Spiromax 12.75 ?g - 202 ?g pdr. inhal. r?cip. multidos. · Seretide 
Airflusal · Airflusal Forspiro 50 Microgramos/500 Microgramos/Inhalacion Polvo Para Inhalacion (Unidosis) · Aldopulmin 50 Microgramos/500 Microgramos/Inhalacion Polvo Para Inhalacion (Unidosis) · Amaira · Amaira 50 Microgramos/100 Microgramos/Inhalacion, Polvo Para Inhalacion (Unidosis) · Amaira 50 Microgramos/250 Microgramos/Inhalacion, Polvo Para Inhalacion (Unidosis) · Anasma · Anasma 25 Microgramos/250 Microgramos/Inhalacion, Suspension Para Inhalacion en Envase a Presion · Anasma 25 Microgramos/50 Microgramos/Inhalacion, Suspension Para Inhalacion en Envase a Presion · ANASMA ACCUHALER 50 microgramos/100 microgramos/INHALACI?N, POLVO PARA INHALACI?N · ANASMA ACCUHALER 50 microgramos/250 microgramos/INHALACI?N, POLVO PARA INHALACI?N · ANASMA ACCUHALER 50 microgramos/500 microgramos/INHALACI?N, POLVO PARA INHALACI?N · BROPAIR SPIROMAX 12,75 microgramos/100 microgramos POLVO PARA INHALACION · BROPAIR SPIROMAX 12,75 microgramos/202 microgramos POLVO PARA INHALACION · Flusamix Easyhaler 50 Microgramos/500 Microgramos/Inhalacion Polvo Para Inhalacion · Inaladuo · INALADUO 25 microgramos/125 microgramos/ INHALACI?N, SUSPENSI?N PARA INHALACI?N EN ENVASE A PRESI?N · INALADUO 25 microgramos/250 microgramos/ INHALACI?N, SUSPENSI?N PARA INHALACI?N EN ENVASE A PRESI?N · INALADUO 25 microgramos/50 microgramos/ INHALACI?N, SUSPENSI?N PARA INHALACI?N EN ENVASE A PRESI?N · INALADUO ACCUHALER 50 microgramos/100 microgramos/INHALACI?N, POLVO PARA INHALACI?N · INALADUO ACCUHALER 50 microgramos/250 microgramos/INHALACI?N, POLVO PARA INHALACI?N · INALADUO ACCUHALER 50 microgramos/500 microgramos/INHALACI?N, POLVO PARA INHALACI?N · Inantol 25 Microgramos/125 Microgramos Suspension Para Inhalacion en Envase a Presion · Inantol 25 Microgramos/250 Microgramos Suspension Para Inhalacion en Envase a Presion · Inhalok · Inhalok Airmaster 50 Microgramos/500 Microgramos/Inhalacion, Polvo Para Inhalacion (Unidosis) · Plusvent · PLUSVENT 25 microgramos/125 microgramos/inhalaci?n, suspensi?n para inhalaci?n envase a presi?n · PLUSVENT 25 microgramos/50 microgramos/inhalaci?n, suspensi?n para inhalaci?n envase a presi?n · PLUSVENT ACCUHALER 50 microgramos/250 microgramos/INHALACI?N, POLVO PARA INHALACI?N · PLUSVENT ACCUHALER 50 microgramos/500 microgramos/INHALACI?N, POLVO PARA INHALACI?N · Salflucombi Easyhaler 50 Microgramos/500 Microgramos/Inhalacion Polvo Para Inhalacion · Salmeterol / Fluticasona · Salmeterol/Fluticasona Cipla 25 Microgramos/250 Micogramos/Inhalacion Suspension Para Inhalacion en Envase a Presion · Salmeterol/Fluticasona Cipla 50 Microgramos/500 Microgramos/Inhalacion, Polvo Para Inhalacion (Unidosis) · Salmeterol/Fluticasona Genetic 25 Microgramos/125 Microgramos/Inhalacion, Suspension Para Inhalacion en Envase a Presion · Salmeterol/Fluticasona Genetic 25 Microgramos/250 Microgramos/Inhalacion, Suspension Para Inhalacion en Envase a Presion · Salmeterol/Fluticasona Genetic 25 Microgramos/50 Microgramos/Inhalacion, Suspension Para Inhalacion en Envase a Presion · Salmeterol/Fluticasona Quasset 25 Microgramos/125 Microgramos/Inhalacion Suspension Para Inhalacion en Envase a Presion · Salmeterol/Fluticasona Quasset 25 Microgramos/250 Microgramos/Inhalacion Suspension Para Inhalacion en Envase a Presion · SEFFALAIR SPIROMAX 12,75 microgramos/100 microgramos POLVO PARA INHALACION · SEFFALAIR SPIROMAX 12.75 microgramos/202 microgramos POLVO PARA INHALACION · Seretide 25 Microgramos/125 Microgramos/Inhalaci?n, Suspensi?n Para Inhalaci?n en Envase a Presi?n · SERETIDE 25 microgramos/250 microgramos/INHALACI?N, SUSPENSI?N PARA INHALACI?N EN ENVASE A PRESI?N · SERETIDE 25 microgramos/50 microgramos/INHALACI?N, SUSPENSI?N PARA INHALACI?N EN ENVASE A PRESI?N · Seretide Accuhaler 50 Microgramos/100 Microgramos/Inhalaci?n, Polvo Para Inhalaci?n · SERETIDE ACCUHALER 50 microgramos/250 microgramos/INHALACI?N, POLVO PARA INHALACI?N. · SERETIDE ACCUHALER 50 microgramos/500 microgramos/INHALACI?N, POLVO PARA INHALACI?N 
Airflusal · Airsales · Airsus · Airsusgen · Aliflus · Biskus · Rolenium · Safubref · Safumix · Salmeterolo e Fluticasone · Salmeterolo e Fluticasone Docgen · Salmeterolo Fluticasone · Seretide 
AIRFLUSAL FORSPIRO 50 micrograme/250 micrograme/doza · AIRFLUSAL FORSPIRO 50 micrograme/500 micrograme/doza · EVERIO 25 micrograme/125 micrograme/doza · EVERIO 25 micrograme/250 micrograme/doza · EVERIO 25 micrograme/50 micrograme/doza · EVERIO AIRMASTER 50 micrograme/100 micrograme · EVERIO AIRMASTER 50 micrograme/250 micrograme · EVERIO AIRMASTER 50 micrograme/500 micrograme · SALMEX 50 micrograme/500 micrograme/doza · Seretide · SERETIDE INHALER CFC FREE 25 ?g/125 ?g · SERETIDE INHALER CFC FREE 25 ?g/50 ?g · SERROFLO 25 micrograme/125 micrograme/doza · SERROFLO 25 micrograme/250 micrograme/doza · ZOREEDA CIPHALER 50 micrograme/250 micrograme · ZOREEDA CIPHALER 50 micrograme/500 micrograme 
Aerivio · AirFluSal · Aloflute · Avenor · Campona · Combisal · Combisal 25micrograms/dose / 125micrograms/dose inhaler · Fixkoh · Fixkoh Airmaster 50micrograms/dose / 100micrograms/dose dry powder inhaler · Fluticasone / Salmeterol · Fusacomb · Fusacomb Easyhaler 50micrograms/dose / 250micrograms/dose dry powder inhaler · Seffalair · Seffalair Spiromax 12.75micrograms/dose / 100micrograms/dose dry powder inhaler · Sereflo · Seretide · Sirdupla · Stalpex 
Aerivio Spiromax · Airexar Spiromax · Airflusal Aerosol · Airflusal Forspiro · AirFluSal Sprayhaler · BroPair Spiromax · Flusacomb · Salflumix Easyhaler · Salmeterol/Fluticasone Neutec · Salmeterol/Fluticasone Zentiva · Salmeterol/Fluticasonpropionat Cipla · Salmeterol/fluticasonpropionat Nordic Prime · Salmex · Seffalair Spiromax · Serefarm · Seretide 
Airflusal Forspiro · Salmeterol/Fluticasone Cipla · Salmeterol/Fluticasone Neutec · Salmex · Seretide 
AirFluSal · AirFluSal Forspiro · Asaris · ASARIS pMDI · Aurodisc · BroPair Spiromax · Comboterol · Duexon · Duexon Pro · Flixodil Combo · Fluticomb · Fullhale Ciphaler · Neuair Airmaster · Salflumix Easyhaler · Salmex · Seffalair Spiromax · Seretide · Symflusal · Veriflo 
Flutisacombo · Flutisamix Easyhaler · Salmeterol/Fluticasone Genetic · Salmex · Seretide 
BroPair Spiromax · Salflumix Easyhaler · Salmeterol/Fluticasone Neutec · Salmex · Seffalair Spiromax · Seretide 
BroPair Spiromax · Salflumix Easyhaler · Salmeterol/Fluticason Orion · Salmeterol/Fluticasone Neutec · Salmex · Seffalair Spiromax · Serefarm · Seretide · Serkep 
AirFluSal Forspiro · BroPair Spiromax · Everio Airmaster · Saflutin · Salflumix Easyhaler · Seffalair Spiromax · Seretide · Serkep 
AirFluSal® Forspiro® · Asaris® · Saldisk® · Seretide
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