R03AK06 - Salmeterol and Fluticasone |
Probably not porphyrinogenic |
PNP |
Rationale
Salmeterol: Substrate for CYP 3A4. Probably insignificant metabolic load. Fluticasone: Probably insignificant systemic exposure. Several references stating non-porphyrinogenic metabolism of glucocorticoids.
Chemical description
Salmeterol: Adrenergic administered in asthma in inhalation aerosol, 50 µg/dose. Gives rise only to very low plasma concentrations. Metabolised in the liver (CYP3A4) producing several metabolites.
Fluticasone: Antiasthmatic antiinflammatory glucocorticoide, administered as inhalation powder (50-250 µg/dose). Systemic exposure about 16% of the taken dose. Rapidly metabolised by CYP3A4 (within 3-4 hours).
IPNet drug reports
Uneventful use reported in 7 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
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9554242 |
| Porphyria Drug Lists | ||
| 2. | French List
Centre Français des Porphyries
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| 3. | EPI List
European Porphyria Initiative No longer maintained
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| 4. | South African List
Porphyria South Africa No longer maintained
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| Other sources | ||
| 5. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
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Tradenames
AirFluSal · BroPair · Saflutin · Salflutin · Salfuler · Salmeterol / Fluticasonpropionaat · Seffalair · Serair · Sereflo · Seretide 
Aerivio · Airflusal · Aurocombo · Brecur · BroPair · Flutisacombo · Flutisamix · Salmeterol / Fluticasone · Seffalair · Seretide 
Fluticasone / Salmeterol · Prop Flut/Salm · Seretide 
Airflusal · Aldopulmin · Amaira · Anasma · Aseriflu · Braquix · Bropair · Flusamix · Inaladuo · Inantol · Inhalok · Plusvent · Salflucombi · Salmeterol / Fluticasona · Salmeterol / Fluticasona Quasset · Seffalair · Seretide 
Airflusol · BroPair · Dimenio · Fluzalto · Safumix · Seffalair · Seretide · Serhalyx · Sirmin · Thoreus 
Aeromex · Airsales · Airsus · Airsusgen · Aliflus · Biskus · Brionex · Bropair · Rolenium · Safubref · Safumix · Salmeterolo e Fluticasone · Salmeterolo Fluticasone · Seffalair · Seretide 
Airflusal · Airpuff · Everio · Salmex · Seretide · Serroflo · Zoreeda 
Salmeterol / Fluticasonpropionat · Seffalair · Seretide 
Aerivio Spiromax 50micrograms/dose / 500micrograms/dose dry powder inhaler · AirFluSal 25micrograms/dose / 125micrograms/dose inhaler · AirFluSal 25micrograms/dose / 250micrograms/dose inhaler · AirFluSal Forspiro 50micrograms/dose / 500micrograms/dose dry powder inhaler · Aloflute 25micrograms/dose / 125micrograms/dose inhaler · Aloflute 25micrograms/dose / 250micrograms/dose inhaler · Avenor 25micrograms/dose / 125micrograms/dose inhaler · Avenor 25micrograms/dose / 250micrograms/dose inhaler · Avenor 25micrograms/dose / 50micrograms/dose inhaler · Campona Airmaster 50micrograms/dose / 100micrograms/dose dry powder inhaler · Campona Airmaster 50micrograms/dose / 250micrograms/dose dry powder inhaler · Campona Airmaster 50micrograms/dose / 500micrograms/dose dry powder inhaler · Combisal 25micrograms/dose / 125micrograms/dose inhaler · Combisal 25micrograms/dose / 250micrograms/dose inhaler · Combisal 25micrograms/dose / 50micrograms/dose inhaler · Fixkoh Airmaster 50micrograms/dose / 100micrograms/dose dry powder inhaler · Fixkoh Airmaster 50micrograms/dose / 250micrograms/dose dry powder inhaler · Fixkoh Airmaster 50micrograms/dose / 500micrograms/dose dry powder inhaler · Fluticasone / Salmeterol · Fusacomb Easyhaler 50micrograms/dose / 250micrograms/dose dry powder inhaler · Fusacomb Easyhaler 50micrograms/dose / 500micrograms/dose dry powder inhaler · Seffalair Spiromax 12.75micrograms/dose / 100micrograms/dose dry powder inhaler · Seffalair Spiromax 12.75micrograms/dose / 202micrograms/dose dry powder inhaler · Sereflo 25micrograms/dose / 125micrograms/dose inhaler · Sereflo 25micrograms/dose / 250micrograms/dose inhaler · Sereflo Ciphaler 50micrograms/dose / 250micrograms/dose dry powder inhaler · Sereflo Ciphaler 50micrograms/dose / 500micrograms/dose dry powder inhaler · Seretide · Sirdupla 25micrograms/dose / 125micrograms/dose inhaler · Sirdupla 25micrograms/dose / 250micrograms/dose inhaler · Stalpex 50micrograms/dose / 500micrograms/dose dry powder inhaler 
Aerivio · Airexar · Airflusal · BroPair · Flusacomb · Salflumix · Salmeterol / Fluticasone · Salmeterol / Fluticasonpropionat · Salmex · Seffalair · Serefarm · Seretide 
Aerivio · Airflusal · Brisomax · Brisomax forte · Fluticasone / Salmeterol · Novucaeli · Relanio · Salflumix · Salmeterol / Fluticasone · Salmeterol / Fluticasonpropionat · Salmeterol / Flutikason · Salmex · Seretide · Veraspir 
Airflusal · Salmeterol / Fluticasone · Salmex · Seretide 
AirFluSal · Asaris · ASARIS pMDI · Aurodisc · Aurospira · BroPair · Comboterol · Duexon · Flixodil · Fluticomb · Fullhale · Neuair · Salflumix · Salmex · Seffalair · Seretide · Symflusal · Veriflo 
Actionflu · Detrubet · Pulmetero · Serecor · Seretide · Serohale · Sibet 
Deventer · Fluticasone / Salmeterol · Rexair · Seretide · Sirdupla · Sirdupla MDI 
Salflumix · Seretide 
Advair · Fluticasone Propionate / Salmeterol · Wixela Inhub 
Flutisacombo · Flutisamix · Salmeterol / Fluticasone · Salmex · Seretide 
BroPair · Salflumix · Salmeterol / Fluticasone · Salmex · Seffalair · Seretide 
BroPair · Salflumix · Salmeterol / Fluticason · Salmeterol / Fluticasone · Salmex · Seffalair · Serefarm · Seretide · Serkep 
Aerivio · Airexar · AirFluSal · BroPair · Everio · Flamerio · Fusamix · Lifsar PulmoJet · Saflutin · Salmeterol / Fluticasone · Seffalair · Seretide · Serkep · seroflo 
AirFluSal · BroPair · Everio · Saflutin · Salflumix · Seffalair · Seretide · Serkep 
Aerivio · Airexar · Airflusal · Bropair · Everio · Flusamer · Lifsar Pulmojet · Salflumix · Seffalair · Seretide · Serkep 
AirFluSal · Asaris · Flonseno · Saldisk · Seretide 
AirFluSal · BroPair · Flonseno · Fusamix · Saldisk · Salmeterol / flutikazon · Seffalair · Seretide · Serzyl 
Airflusan · Flamerio · Flonseno · Lifsar PulmoJet · Salflumix · Salmeterol / flutikazon · Seretide · Serkep · Viani 
Airflusan · Asthmex · Bropair · Everio · Fullhale · Salflumix · Seffalair · Seretide · Veriflo · Zoreeda 
Aerivio · Airexar · BroPair · Labazenit · Seffalair 
Advair · Cyplos